| A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing | |
| Li, Chunyang1; He, Xiaojun2; Li, Qingfeng3; Lv, Mingzhi1; Shen, Jianliang2,4; Jin, Lin3; He, Deyan1 | |
| 2023-01-13 | |
| Source Publication | NPG Asia Materials Impact Factor & Quartile |
| ISSN | 1884-4049 |
| Volume | 15Issue:1 |
| page numbers | 10 |
| Abstract | During wound healing, oxygen availability and the anti-inflammatory microenvironment play an important role in the formation of new tissue. However, providing continuous and controllable oxygen around the injured tissue while inhibiting inflammation and realizing the synergistic effect of oxygen supply and anti-inflammation is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and the inflammatory microenvironment, a photothermal response-assisted strategy was developed in this study. We prepared a composite hydrogel system of polydopamine-hyaluronic acid (PDA-HA) hydrogel-loaded calcium peroxide-indocyanine green combined with lauric acid and manganese dioxide (CaO2-ICG@LA@MnO2) nanoparticles that showed excellent photothermal performance under near-infrared (NIR) irradiation and realized the on-off release of oxygen and reactive oxygen species (ROS). Controllable and sustainable oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believe that the system we have developed can be used in a new approach for treating chronic wounds. |
| Publisher | NATURE PORTFOLIO |
| DOI | 10.1038/s41427-022-00456-7 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| WOS ID | WOS:000918377000002 |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/499076 |
| Collection | 兰州大学 |
| Corresponding Author | Jin, Lin; He, Deyan |
| Affiliation | 1.Lanzhou Univ, Sch Mat & Energy, Lanzhou 730000, Peoples R China; 2.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou 325035, Peoples R China; 3.Zhoukou Normal Univ, Henan Int Joint Lab Biomed Nanomat, Zhoukou 466001, Peoples R China; 4.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Chunyang,He, Xiaojun,Li, Qingfeng,et al. A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing[J]. NPG Asia Materials,2023,15(1). |
| APA | Li, Chunyang.,He, Xiaojun.,Li, Qingfeng.,Lv, Mingzhi.,Shen, Jianliang.,...&He, Deyan.(2023).A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing.NPG Asia Materials,15(1). |
| MLA | Li, Chunyang,et al."A photothermal-response oxygen release platform based on a hydrogel for accelerating wound healing".NPG Asia Materials 15.1(2023). |
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