| Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels | |
| Ding, Yan-Yan2; Sun, Yu2,3; Luo, Xiong-Fei2; Zhang, Shao-Yong3; Wang, Rui4; Yang, Zhi-Gang1,2; Wang, Jing-Ru2; Zhang, Bao-Qi2; Zhang, Zhi-Jun1,2; Ma, Yue2; An, Jun-Xia2; Zhou, Han2; Liu, Ying-Qian1,2,3,5 | |
| 2023-02 | |
| Online publication date | 2023-02 |
| Source Publication | PEST MANAGEMENT SCIENCE Impact Factor & Quartile |
| ISSN | 1526-498X |
| Volume | 79Issue:6Pages:2135-2146 |
| page numbers | 12 |
| Abstract | BACKGROUNDThe resistance of traditional chemical fungicides to plant pathogenic fungi and the threats to the safety of humans and the environment highlight an urgent need to find safe and efficient alternatives to chemical fungicides. Owing to the wide spectrum of antifungal activities, low persistence and nontoxicity to mammals and aquatic life, essential oils have considerable potential as low-risk pesticides. In this study, the essential oil and the main components of Angelica sinensis (Oliv.) Diels (Danggui) were extracted, analyzed by GC-MS, and evaluated for their antifungal activities against six plant pathogenic fungi. RESULTS3-butylidenephthalide (3-BPH) showed the best antifungal activity against Fusarium graminearum with an EC50 value of 14.35 mu g mL(-1). The antifungal mechanistic studies revealed that 3-BPH induced the generation of endogenous ROS to cause lipid peroxidation of the cell membrane and inhibited the biosynthesis of ergosterol, thereby causing the cell membrane damaged to exert its fungicidal activity. Significantly, 3-BPH could reduce deoxynivalenol production compared to the control. CONCLUSIONThis study demonstrated the potent fungicidal activity of natural phthalide compound 3-BPH and highlighted its potential as an alternative agent to control F. graminearum. (c) 2023 Society of Chemical Industry. |
| Keyword | Angelica sinensis 3-butylidenephthalide antifungal activity Fusarium graminearum mechanism |
| Publisher | JOHN WILEY & SONS LTD |
| DOI | 10.1002/ps.7389 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Agriculture ; Entomology |
| WOS Subject | Agronomy ; Entomology |
| WOS ID | WOS:000934623500001 |
| Original Document Type | Article ; Early Access |
| PMID | 36721354 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/499329 |
| Collection | 兰州大学 |
| Corresponding Author | Yang, Zhi-Gang; Zhang, Zhi-Jun; Liu, Ying-Qian |
| Affiliation | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China; 3.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China; 4.Weifang Univ, Key Lab Biochem & Mol Biol Univ Shandong Prov, Weifang, Peoples R China; 5.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou, Peoples R China |
| Recommended Citation GB/T 7714 | Ding, Yan-Yan,Sun, Yu,Luo, Xiong-Fei,et al. Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels[J]. PEST MANAGEMENT SCIENCE,2023,79(6):2135-2146. |
| APA | Ding, Yan-Yan.,Sun, Yu.,Luo, Xiong-Fei.,Zhang, Shao-Yong.,Wang, Rui.,...&Liu, Ying-Qian.(2023).Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels.PEST MANAGEMENT SCIENCE,79(6),2135-2146. |
| MLA | Ding, Yan-Yan,et al."Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels".PEST MANAGEMENT SCIENCE 79.6(2023):2135-2146. |
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