| Drug repurposing strategy II: from approved drugs to agri-fungicide leads | |
| An, Jun-Xia1,2; Ma, Yue1; Zhao, Wen-Bin1; Hu, Yong-Mei1; Wang, Yi-Rong1; Zhang, Zhi-Jun1; Luo, Xiong-Fei1; Zhang, Bao-Qi1; Ding, Yan-Yan1; Liu, Ying-Qian1,2,3 | |
| 2023-03 | |
| Online publication date | 2023-01 |
| Source Publication | JOURNAL OF ANTIBIOTICS Impact Factor & Quartile |
| ISSN | 0021-8820 |
| Volume | 76Issue:3Pages:131-182 |
| page numbers | 52 |
| Abstract | Epidemic diseases of crops caused by fungi deeply affected the course of human history and processed a major restriction on social and economic development. However, with the enormous misuse of existing antimicrobial drugs, an increasing number of fungi have developed serious resistance to them, making the diseases caused by pathogenic fungi even more challenging to control. Drug repurposing is an attractive alternative, it requires less time and investment in the drug development process than traditional R&D strategies. In this work, we screened 600 existing commercially available drugs, some of which had previously unknown activity against pathogenic fungi. From the primary screen at a fixed concentration of 100 mu g/mL, 120, 162, 167, 85, 102, and 82 drugs were found to be effective against Rhizoctonia solani, Sclerotinia sclerotiorum, Botrytis cinerea, Phytophthora capsici, Fusarium graminearum and Fusarium oxysporum, respectively. They were divided into nine groups lead compounds, including quinoline alkaloids, benzimidazoles/carbamate esters, azoles, isothiazoles, pyrimidines, pyridines, piperidines/piperazines, ionic liquids and miscellaneous group, and simple structure-activity relationship analysis was carried out. Comparison with fungicides to identify the most promising drugs or lead structures for the development of new antifungal agents in agriculture. |
| Publisher | SPRINGERNATURE |
| DOI | 10.1038/s41429-023-00594-2 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| WOS Subject | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| WOS ID | WOS:000920986800001 |
| Original Document Type | Article |
| PMID | 36707717 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/499623 |
| Collection | 兰州大学 |
| Corresponding Author | Liu, Ying-Qian |
| Affiliation | 1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China; 3.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China |
| Recommended Citation GB/T 7714 | An, Jun-Xia,Ma, Yue,Zhao, Wen-Bin,et al. Drug repurposing strategy II: from approved drugs to agri-fungicide leads[J]. JOURNAL OF ANTIBIOTICS,2023,76(3):131-182. |
| APA | An, Jun-Xia.,Ma, Yue.,Zhao, Wen-Bin.,Hu, Yong-Mei.,Wang, Yi-Rong.,...&Liu, Ying-Qian.(2023).Drug repurposing strategy II: from approved drugs to agri-fungicide leads.JOURNAL OF ANTIBIOTICS,76(3),131-182. |
| MLA | An, Jun-Xia,et al."Drug repurposing strategy II: from approved drugs to agri-fungicide leads".JOURNAL OF ANTIBIOTICS 76.3(2023):131-182. |
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