兰州大学机构库 >药学院
Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi
Li, Hai-Xin1; Luo, Xiong-Fei1; Deng, Peng1; Zhang, Shao-Yong2; Zhou, Han1; Ding, Yan Yan1; Wang, Yi-Rong1; Liu, YQ(刘映前)1,2,3; Zhang, ZJ(张智军)1
2023-02-08
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0021-8561
Volume71Issue:5Pages:2301-2312
AbstractA series of quinoline derivatives were designed and synthesized by the structural simplification of cryptolepine and evaluated for their fungicidal activity against six phytopathogenic fungi. Most of these compounds exhibited remarkable activities against Botrytis cinereain vitro. Among them, compounds A18 and L01 showed superior antifungal activity. Significantly, compared to cryptolepine, compound A18 exhibited broad-spectrum inhibitory activities against B. cinerea, Sclerotinia sclerotiorum, Rhizoctonia solani, Phytophthora capsica, Magnaporthe oryzae, and Fusarium graminearum with the respective EC50 values of 0.249, 1.569, 3.915, 0.505, 0.246, and 4.999 μg/mL. Compound L01 displayed the best antifungal activity against B. cinerea with an EC50 value of 0.156 μg/mL. Preliminary mechanistic studies showed that compound A18 could inhibit spore germination, affect the permeability of the cell membrane, increase the content of reactive oxygen species, and affect the morphology of hyphae and cells. Moreover, compound A18 showed excellent in vivo protective effect against B. cinerea, which was more potent than pyrimethanil and equitant to cryptolepine. These results evidenced that compound A18 displayed superior fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases. © 2023 American Chemical Society.
KeywordFungi Fungicides Antifungal activities Antifungals Botrytis cinerea Cryptolepine Fungicidal activity Phytopathogenic fungi Quinoline derivative Structural simplification Structure-activity relationships Synthesised cryptolepine structural simplification antifungal activity structure-activity relationship
PublisherAmerican Chemical Society
DOI10.1021/acs.jafc.2c07575
Indexed ByEI ; SCIE
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000963528600001
EI Accession Number20230713586157
EI KeywordsCytology
EI Classification Number461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 804.1 Organic Compounds
Original Document TypeJournal article (JA) ; Article
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/500432
Collection药学院
Corresponding AuthorLiu, Ying-Qian; Zhang, Zhi-Jun
Affiliation
1.School of Pharmacy, Lanzhou University, Lanzhou; 730000, China;
2.Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou; 313000, China;
3.State Key Laboratory of Grassland Agro-ecosystems, Lanzhou University, Lanzhou; 730000, China
First Author AffilicationSchool of Pharmacy
Corresponding Author AffilicationSchool of Pharmacy;  Lanzhou University
First Signature AffilicationSchool of Pharmacy
Recommended Citation
GB/T 7714
Li, Hai-Xin,Luo, Xiong-Fei,Deng, Peng,et al. Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(5):2301-2312.
APA Li, Hai-Xin.,Luo, Xiong-Fei.,Deng, Peng.,Zhang, Shao-Yong.,Zhou, Han.,...&Zhang, Zhi-Jun.(2023).Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(5),2301-2312.
MLA Li, Hai-Xin,et al."Structural Simplification of Cryptolepine to Obtain Novel Antifungal Quinoline Derivatives against Phytopathogenic Fungi".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.5(2023):2301-2312.
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