| Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds | |
Shi, Yuting1; Yu, Wenwen2; Liang, Xiaoqin3; Cheng, Ju4; Cao, Yufei1; Liu, Mingsheng1; Fang, Yu1; Yang, Zheng1; Liu, Hongbin2; Wei, H(魏华)1 ; Zhao, GH(赵光辉)1 | |
| 2023-05-01 | |
| Source Publication | CARBOHYDRATE POLYMERS Impact Factor & Quartile |
| ISSN | 0144-8617 |
| Volume | 307 |
| Abstract | Preventing arterial hemorrhage by intervening within the first few minutes is critical to the patient's life. Hemostatic materials have been developed over the last decades to address this issue, nevertheless these materials alone do not contribute to improve the survival effects in many extreme conditions, which is usually caused by penetrating arterial bleeding wounds that are incompressible and deep arterial bleeding with irregularly shapes. It is well known that, after calcium ion stimulation, many intriguing changes occurred in the major components of plasma, including the activation of several coagulation factors, such as the conversion of fibrinogen to fibrin, prothrombin to thrombin, and so on. Therefore, we constructed an expansion sponge with interpenetrating network based on chitosan and plasma, while various activated coagulation factors in plasma were also loaded into the pore structure of chitosan sponges. The prepared CS-PG sponge is capable of providing a simpler and more efficient method for treating high-pressure arterial bleeding wounds, which includes three steps: Rapid sealing and adhension, Thrombin catalysis and Activated autocoagulation. As the next generation bioactive materials, compared to conventional hemostatic materials, CS-PG sponge demonstrated superior hemostatic characteristics in both rabbit femoral artery damage and rat liver injury models. © 2023 Elsevier Ltd |
| Keyword | Coagulation Enzymes Pore structure Bleedings Calcium ions Coagulation factor Extreme conditions Fibrin Haemorrage Haemostasis Network expansion Thrombin Ultra-fast |
| Publisher | Elsevier Ltd |
| DOI | 10.1016/j.carbpol.2023.120590 |
| Indexed By | EI |
| Language | 英语 |
| EI Accession Number | 20230613568051 |
| EI Keywords | Chitosan |
| EI Classification Number | 802.3 Chemical Operations ; 804.1 Organic Compounds ; 931.2 Physical Properties of Gases, Liquids and Solids |
| Original Document Type | Journal article (JA) |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/500676 |
| Collection | 化学化工学院 |
| Corresponding Author | Zhao, Guanghui |
| Affiliation | 1.State Key Laboratory of Applied Organic Chemistry, Institute of Biochemical Engineering & Environmental Technology, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China; 2.The Second Clinical Medical College, Lanzhou University, Lanzhou; 730000, China; 3.Department of Pathology, Gansu Province People's Hospital, Lanzhou; 730000, China; 4.School of Basic Medical Science, Lanzhou University, Lanzhou; 730000, China |
| First Author Affilication | College of Chemistry and Chemical Engineering |
| Corresponding Author Affilication | College of Chemistry and Chemical Engineering |
| Recommended Citation GB/T 7714 | Shi, Yuting,Yu, Wenwen,Liang, Xiaoqin,et al. Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds[J]. CARBOHYDRATE POLYMERS,2023,307. |
| APA | Shi, Yuting.,Yu, Wenwen.,Liang, Xiaoqin.,Cheng, Ju.,Cao, Yufei.,...&Zhao, Guanghui.(2023).Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds.CARBOHYDRATE POLYMERS,307. |
| MLA | Shi, Yuting,et al."Interpenetrating network expansion sponge based on chitosan and plasma for ultrafast hemostasis of arterial bleeding wounds".CARBOHYDRATE POLYMERS 307(2023). |
| Files in This Item: | There are no files associated with this item. | ||||
