| A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy | |
| Li, Youyou1; Han, Wenbo1; Gong, Deyan3; Luo, Taokun1; Fan, Yingjie1; Mao, Jianming1; Qin, Wenwu3; Lin, Wenbin1,2 | |
| 2023 | |
| Online publication date | 2023-04 |
| Source Publication | Chemical Science Impact Factor & Quartile |
| ISSN | 2041-6520 |
| Volume | 14Issue:19Pages:5106-5115 |
| page numbers | 10 |
| Abstract | We report the self-assembly of amphiphilic BDQ photosensitizers into lysosome-targeting nanophotosensitizer BDQ-NP for highly effective photodynamic therapy (PDT). Molecular dynamics simulation, live cell imaging, and subcellular colocalization studies showed that BDQ strongly incorporated into lysosome lipid bilayers to cause continuous lysosomal membrane permeabilization. Upon light irradiation, the BDQ-NP generated a high level of reactive oxygen species to disrupt lysosomal and mitochondrial functions, leading to exceptionally high cytotoxicity. The intravenously injected BDQ-NP accumulated in tumours to achieve excellent PDT efficacy on subcutaneous colorectal and orthotopic breast tumor models without causing systemic toxicity. BDQ-NP-mediated PDT also prevented metastasis of breast tumors to the lungs. This work shows that self-assembled nanoparticles from amphiphilic and organelle-specific photosensitizers provide an excellent strategy to enhance PDT. © 2023 The Royal Society of Chemistry |
| Keyword | Cell proliferation Lipid bilayers Molecular dynamics Photosensitizers Self assembly Tumors Amphiphilics Breast tumour Co-localization studies Dynamics simulation Light irradiations Live-cell imaging Lysosomal membranes Membrane permeabilization Photosensitiser Sub-cellular |
| Publisher | Royal Society of Chemistry |
| DOI | 10.1039/d3sc00455d |
| Indexed By | EI ; SCIE ; IC |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000975284700001 |
| EI Accession Number | 20231814039670 |
| EI Keywords | Photodynamic therapy |
| EI Classification Number | 461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 741.1 Light/Optics ; 801.4 Physical Chemistry ; 951 Materials Science |
| Original Document Type | Article in Press |
| PMID | 37206384 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/500683 |
| Collection | 兰州大学 化学化工学院 |
| Corresponding Author | Lin, Wenbin |
| Affiliation | 1.Department of Chemistry, The University of Chicago, Chicago; IL; 60637, United States; 2.Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, Chicago; IL; 60637, United States; 3.Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou; 730000, China |
| Recommended Citation GB/T 7714 | Li, Youyou,Han, Wenbo,Gong, Deyan,et al. A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy[J]. Chemical Science,2023,14(19):5106-5115. |
| APA | Li, Youyou.,Han, Wenbo.,Gong, Deyan.,Luo, Taokun.,Fan, Yingjie.,...&Lin, Wenbin.(2023).A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy.Chemical Science,14(19),5106-5115. |
| MLA | Li, Youyou,et al."A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy".Chemical Science 14.19(2023):5106-5115. |
| Files in This Item: | There are no files associated with this item. | ||||
