| Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives | |
Du, Sha-Sha1; Luo, Xiong-Fei1; An, Jun-Xia1,3; Zhang, ZJ(张智军)1 ; Zhang, Shao-Yong; Wang, Yi-Rong1; Ding, Yan-Yan1; Jiang, Wei-Qi1; Zhang, Bao-Qi1; Ma, Yue1; Zhou, Yong1; Hu, Yong-Mei1; Liu, YQ(刘映前)1,2,3,4 | |
| 2023-05 | |
| Source Publication | PEST MANAGEMENT SCIENCE
 |
| ISSN | 1526-498X |
| Abstract | BackgroundThe unreasonable use of chemical fungicides causes common adverse consequences that not only affect the environment, but also cause resistance and resurgence problems of plant pathogens, which are extremely harmful to human health, the economy, and the environment. Based on the rich biological activities of boron-based compounds, 82 phenylboronic acid derivatives were selected and their antifungal activities against six agricultural plant pathogens were determined. Combined with transcriptomics tools, the mechanism of action of compound A49 (2-chloro-5-trifluoromethoxybenzeneboronic acid) against Botrytis cinerea Pers (B. cinerea) was studied. ResultsThe EC50 values of compounds A24, A25, A30, A31, A36, A41, A49 and B23 against all six fungi were under 10 mu g/mL. Compound A49 displayed significant activity against B. cinerea (EC50 = 0.39 mu g/mL), which was better than that of commercial fungicide boscalid (EC50 = 0.55 mu g/mL). A49 not only inhibited the germination of B. cinerea spores, but also caused abnormal cell morphology, loss of cell membrane integrity, enhanced cell membrane permeability, and accumulation of intracellular reactive oxygen species. Further findings showed that A49 reduced cellular antioxidant activity, and peroxidase and catalase activities. Transcriptomic results indicated that A49 could degrade intracellular redox processes and alter the metabolism of some amino acids. Meanwhile, A49 showed obvious activity in vivo and low cytotoxicity to mammal cells. ConclusionThe boron-containing small molecule compounds had high efficiency and broad-spectrum antifungal activities against six plant pathogens, and are expected to be candidate compounds for a new class of antifungal drugs. (c) 2023 Society of Chemical Industry. |
| Keyword | boron-containing compounds antifungal activity structure-activity relationship antifungal mechanism Botrytis cinerea |
| Publisher | JOHN WILEY & SONS LTD |
| DOI | 10.1002/ps.7451 |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Agriculture ; Entomology |
| WOS Subject | Agronomy ; Entomology |
| WOS ID | WOS:000977799900001 |
| Original Document Type | Article ; Early Access |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/501501 |
| Collection | 药学院 |
| Corresponding Author | Liu, Ying-Qian |
| Affiliation | 1.Lanzhou Univ, Sch Pharm, Lanzhou, Peoples R China; 2.199 Donggang West Rd, Lanzhou, Gansu, Peoples R China; 3.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou, Peoples R China; 4.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China |
| First Author Affilication | School of Pharmacy |
| Corresponding Author Affilication | School of Pharmacy; College of Pastoral Agriculture Science and Technology; School of Life Sciences |
| Recommended Citation GB/T 7714 | Du, Sha-Sha,Luo, Xiong-Fei,An, Jun-Xia,et al. Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives[J]. PEST MANAGEMENT SCIENCE,2023. |
| APA | Du, Sha-Sha.,Luo, Xiong-Fei.,An, Jun-Xia.,Zhang, Zhi-Jun.,Zhang, Shao-Yong.,...&Liu, Ying-Qian.(2023).Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives.PEST MANAGEMENT SCIENCE. |
| MLA | Du, Sha-Sha,et al."Exploring boron applications in modern agriculture: Antifungal activities and mechanisms of phenylboronic acid derivatives".PEST MANAGEMENT SCIENCE (2023). |
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