| Photodynamic therapy improves the outcome of immune checkpoint inhibitors via remodelling anti-tumour immunity in patients with gastric cancer | |
| 2023-06-19 | |
| Online publication date | 2023-06 |
| Source Publication | Gastric Cancer Impact Factor & Quartile |
| ISSN | 1436-3291 |
| Volume | 26Issue:5Pages:798-813 |
| page numbers | 16 |
| Abstract | BackgroundPhotodynamic therapy (PDT) plays an immunoregulatory role in tumours. Here, we conducted a retrospective patient analysis to evaluate the effectiveness of PDT plus immune checkpoint inhibitors (ICIs) in gastric cancer. Further, we performed a dynamic analysis of gastric cancer patients receiving PDT to clarify its effects on anti-tumour immunity.MethodsForty ICI-treated patients that received PDT or not were retrospectively analysed. Five patients with gastric adenocarcinoma were enrolled for sample collection before and after PDT. Single-cell RNA/T cell receptor (TCR) sequencing, flow cytometry and histological exanimation were used to analyse the collected specimens.ResultsPatients in PDT group had a significantly better OS after ICI treatment than those in No PDT group. Single-cell analysis identified ten cell types in gastric cancer tissues and four sub-populations of T cells. Immune cell infiltration increased in the tumours after PDT and the circular immune cells showed consistent alterations. TCR analysis revealed a specific clonal expansion after PDT in cytotoxic T lymphocytes (CTL), but a constriction in Tregs. The B2M gene is upregulated in tumour cells after PDT and is associated with immune cell infiltration. Several pathways involving the positive regulation of immunity were enriched in tumour cells in the post-PDT group. The interactions following PDT were increased between tumour cells and effector cells but decreased between Tregs and other immune cells. Some co-stimulatory signaling emerged, whereas co-inhibitory signaling disappeared in intercellular communication after PDT.ConclusionsPDT elicits an anti-tumour response through various mechanisms and is promising as an adjuvant to enhance ICI benefit. |
| Keyword | Photodynamic therapy Gastric cancer Immune cells Single-cell analysis Anti-tumour |
| Publisher | SPRINGER |
| DOI | 10.1007/s10120-023-01409-x |
| Indexed By | SCIE |
| Language | 英语 |
| WOS Research Area | Oncology ; Gastroenterology & Hepatology |
| WOS Subject | Oncology ; Gastroenterology & Hepatology |
| WOS ID | WOS:001010672000001 |
| Original Document Type | Article ; Early Access |
| PMID | 37335366 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/530236 |
| Collection | 兰州大学 |
| Corresponding Author | Chen, Hao |
| Affiliation | 1.Lanzhou Univ, Hosp 2, Dept Tumor Surg, Lanzhou, Peoples R China; 2.Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China; 3.Lanzhou Univ, Hosp 1, Dept Oncol, Lanzhou, Peoples R China; 4.Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, Lanzhou, Peoples R China |
| Recommended Citation GB/T 7714 | Yu, Yang,Xu, Bo,Xiang, Lin,et al. Photodynamic therapy improves the outcome of immune checkpoint inhibitors via remodelling anti-tumour immunity in patients with gastric cancer[J]. Gastric Cancer,2023,26(5):798-813. |
| APA | Yu, Yang.,Xu, Bo.,Xiang, Lin.,Ding, Tianlong.,Wang, Na.,...&Chen, Hao.(2023).Photodynamic therapy improves the outcome of immune checkpoint inhibitors via remodelling anti-tumour immunity in patients with gastric cancer.Gastric Cancer,26(5),798-813. |
| MLA | Yu, Yang,et al."Photodynamic therapy improves the outcome of immune checkpoint inhibitors via remodelling anti-tumour immunity in patients with gastric cancer".Gastric Cancer 26.5(2023):798-813. |
| Files in This Item: | There are no files associated with this item. | ||||
