| Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG | |
| Shao, Xuexiao1; Yan, Danfeng7,8; Kong, Wenwen1; Sun, Shuting5; Liao, Mei6,7; Ou, Wenwen6,7; Zhang, Yan6,7; Zheng, Fang1; Li, Xiaowei1; Li, Lingjiang6,7; Hu, Bin1,2,3,4,5 | |
| 2023-04 | |
| Online publication date | 2023-02 |
| Source Publication | PSYCHIATRY RESEARCH Impact Factor & Quartile |
| ISSN | 0165-1781 |
| Volume | 322 |
| Abstract | Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood. Moreover, most of the current studies lack objective biological indicators to evaluate the changes of nitrous oxide-induced brain function for TRD. Therefore, this study assessed the effect of nitrous oxide on brain function for TRD based on event-related po-tential (ERP) components and functional connectivity networks (FCNs) methods. In this randomized, longitu-dinal, placebo-controlled trial, all TRD participants were divided into two groups to receive either a 1-hour inhalation of nitrous oxide or a placebo treatment, and they took part in the same task-state electroencephalo-gram (EEG) experiment before and after treatment. The experimental results showed that nitrous oxide improved depressive symptoms better than placebo in terms of 17-Hamilton Depression Rating Scale score (HAMD-17). Statistical analysis based on ERP components showed that nitrous oxide-induced significant differences in amplitude and latency of N1, P1, N2, P2. In addition, increased brain functional connectivity was found after nitrous oxide treatment. And the change of network metrics has a significant correlation with decreased depressive symptoms. These findings may suggest that nitrous oxide improves depression symptoms for TRD by modifying brain function. |
| Keyword | Nitrous oxide Treatment-resistant depression Task-state EEG Event-related potential Functional connectivity networks |
| Publisher | ELSEVIER IRELAND LTD |
| DOI | 10.1016/j.psychres.2023.115072 |
| Indexed By | SCIE ; SSCI |
| Language | 英语 |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:000991565500001 |
| Original Document Type | Article |
| PMID | 36791487 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/530349 |
| Collection | 兰州大学 |
| Corresponding Author | Li, Xiaowei; Li, Lingjiang; Hu, Bin |
| Affiliation | 1.Lanzhou Univ, Sch Informat Sci & Engn, Gansu Prov Key Lab Wearable Comp, Lanzhou, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China; 3.Chinese Acad Sci, Joint Res Ctr Cognit Neurosensor Technol Lanzhou U, Beijing, Peoples R China; 4.Lanzhou Univ, Engn Res Ctr Open Source Software & Real Time Syst, Minist Educ, Lanzhou, Peoples R China; 5.Beijing Inst Technol, Inst Engn Med, Brain Hlth Engn Lab, Beijing, Peoples R China; 6.Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China; 7.Cent South Univ, China Natl Technol Inst Mental Disorders, Hunan Technol Inst Psychiat, Mental Hlth Inst,China Natl Clin Res Ctr Mental Di, Changsha 410011, Hunan, Peoples R China; 8.Taiyuan Fifth Peoples Hosp, Shanxi Mental Hlth Ctr, Taiyuan 030045, Shanxi, Peoples R China |
| Recommended Citation GB/T 7714 | Shao, Xuexiao,Yan, Danfeng,Kong, Wenwen,et al. Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG[J]. PSYCHIATRY RESEARCH,2023,322. |
| APA | Shao, Xuexiao.,Yan, Danfeng.,Kong, Wenwen.,Sun, Shuting.,Liao, Mei.,...&Hu, Bin.(2023).Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG.PSYCHIATRY RESEARCH,322. |
| MLA | Shao, Xuexiao,et al."Brain function changes reveal rapid antidepressant effects of nitrous oxide for treatment-resistant depression:Evidence from task-state EEG".PSYCHIATRY RESEARCH 322(2023). |
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