兰州大学机构库
枸杞多糖对骨质疏松症大鼠血清中TGF-β1和NOS含量的影响
任小军1; 苏春红1; 陈永刚1; 移志刚1; 董平1; 刘文忠1; 丁界先1; 王一农2
2020-03-15
Source Publication甘肃医药   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1004-2725
Volume39Issue:03Pages:196-197+204
page numbers3
Abstract目的:观察枸杞多糖(LBP)对去势雌性骨质疏松症大鼠血清中转化生长因子β1(TGF-β1)、一氧化氮合成酶(NOS)含量的影响,验证LBP防治骨质疏松症的疗效,探讨其可能的作用机理。方法:选取50只3月龄雌性SD大鼠,随机分为5组,分别是SHAM组(空白对照组)、OVX组(切除双侧卵巢去势组)、E2组(切除双侧卵巢去势+己烯雌酚干预组)、L组(切除双侧卵巢去势+中剂量枸杞多糖干预组)和H组(切除双侧卵巢去势+高剂量枸杞多糖干预组),每组10只。用切除雌性SD大鼠双侧卵巢的方法制备骨质疏松症模型,术后常规饲养两个月,骨密度检测证实骨质疏松症造模成果,然后用药物进行干预,90天后检测大鼠血清中TGF-β1和NOS的含量。结果:药物干预90天后,L组和H组血清中NOS和TGF-β1的含量较OVX组升高(P<0.05),但与SHAM组和E2组比较差异无统计学意义(P>0.05)。结论:LBP可通过血清中NOS、TGF-β1因子途径干预SD大鼠骨质疏松症的进展。
Keyword骨质疏松症 枸杞多糖 去势大鼠 局部因子 TGF-β1 NOS
DOI10.15975/j.cnki.gsyy.2020.03.002
URL查看原文
Language中文
Subtype学术期刊
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Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/556938
Collection兰州大学
第二临床医学院
Affiliation
1.兰州大学第二医院;
2.宁夏回族自治区人民医院
First Author AffilicationSecond Clinical School
Recommended Citation
GB/T 7714
任小军,苏春红,陈永刚,等. 枸杞多糖对骨质疏松症大鼠血清中TGF-β1和NOS含量的影响[J]. 甘肃医药,2020,39(03):196-197+204.
APA 任小军.,苏春红.,陈永刚.,移志刚.,董平.,...&王一农.(2020).枸杞多糖对骨质疏松症大鼠血清中TGF-β1和NOS含量的影响.甘肃医药,39(03),196-197+204.
MLA 任小军,et al."枸杞多糖对骨质疏松症大鼠血清中TGF-β1和NOS含量的影响".甘肃医药 39.03(2020):196-197+204.
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