兰州大学机构库
Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-Based Multi-Omics Study Short title: Profile: Guangzhou Nutrition and Health Study
2023-10-07
Online publication date2023-10
Source PublicationJOURNAL OF EPIDEMIOLOGY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN0917-5040
page numbers23
AbstractBackground: The Guangzhou Nutrition and Health Study (GNHS) aims to assess the determinants of metabolic disease in nutritional aspects, as well as other environmental and genetic factors, and explore possible biomarkers and mechanisms with multi-omics integration.Methods: The population-based sample of adults in Guangzhou, China (baseline: 40-83 years old; n = 5118) was followed up about every 3 years. All will be tracked via on-site follow-up and health information systems. We assessed detailed information on lifestyle factors, physical activities, dietary assessments, psychological health, cognitive function, body measurements, and muscle function. Instrument tests included dual-energy X-ray absorptiometry scanning, carotid artery and liver ultrasonography evaluations, vascular endothelial function evaluation, upper-abdomen and brain magnetic resonance imaging, and 14-d real-time continuous glucose monitoring tests. We also measured multi-omics, including host genome-wide genotyping, serum metabolome and proteome, gut microbiome (16S rRNA sequencing, metagenome, and internal transcribed spacer 2 sequencing), and fecal metabolome and proteome.Results: The baseline surveys were conducted from 2008 to 2015. Now, we have completed 3 waves. The 3rd and 4th follow-ups have started but have yet to end. A total of 5118 participants aged 40-83 took part in the study. The median age at baseline was approximately 59.0 years and the proportion of female participants was about 69.4%. Among all the participants, 3628 (71%) completed at least one on-site follow-up with a median duration of 9.48 years.Conclusion: The cohort will provide data that have been influential in establishing the role of nutrition in metabolic diseases with multi-omics.
KeywordMetabolic health Population-based Cohort study Nutrition Multi omics
PublisherJAPAN EPIDEMIOLOGICAL ASSOC
DOI10.2188/jea.JE20230108
Indexed BySCIE
Language英语
WOS Research AreaPublic, Environmental & Occupational Health
WOS SubjectPublic, Environmental & Occupational Health
WOS IDWOS:001088764800001
Original Document TypeArticle ; Early Access
PMID 37813622
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568252
Collection兰州大学
公共卫生学院
Corresponding AuthorLing, Wenhua; Zheng, Ju-Sheng; Chen, Yu-Ming
Affiliation
1.Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510275, Peoples R China;
2.Jinan Univ, Sch Med, Dept Epidemiol, Guangzhou 510632, Peoples R China;
3.Southern Med Univ, Foshan Inst Fetal Med, Dept Obstet, Affiliated Maternal & Child Hlth Hosp Foshan, Foshan 528000, Peoples R China;
4.Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou 310024, Peoples R China;
5.Sun Yat Sen Mem Hosp, Dept Clin Nutr, Guangzhou 510120, Peoples R China;
6.Southern Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Peoples R China;
7.Hainan Med Univ, Int Sch Publ Hlth & One Hlth, Haikou 571199, Peoples R China;
8.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Global Hlth Res Ctr, Guangzhou, Peoples R China;
9.Zhengzhou Univ, Dept Nutr, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China;
10.Nantong Univ, Sci Educ Sect, Affiliated Matern & Child Hlth Care Hosp, Nantong, Peoples R China;
11.Nantong Univ, Dept Child Healthcare, Affiliated Matern & Child Hlth Care Hosp, Nantong, Peoples R China;
12.Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol, Lanzhou, Peoples R China;
13.Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Peoples R China;
14.Sun Yat sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou 510080, Peoples R China;
15.Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, 18 Shilongshan Rd, Hangzhou, Peoples R China
Recommended Citation
GB/T 7714
Ling, Chu-Wen,Zhong, Haili,Zeng, Fang-fang,et al. Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-Based Multi-Omics Study Short title: Profile: Guangzhou Nutrition and Health Study[J]. JOURNAL OF EPIDEMIOLOGY,2023.
APA Ling, Chu-Wen.,Zhong, Haili.,Zeng, Fang-fang.,Chen, Gengdong.,Fu, Yuanqing.,...&Chen, Yu-Ming.(2023).Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-Based Multi-Omics Study Short title: Profile: Guangzhou Nutrition and Health Study.JOURNAL OF EPIDEMIOLOGY.
MLA Ling, Chu-Wen,et al."Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-Based Multi-Omics Study Short title: Profile: Guangzhou Nutrition and Health Study".JOURNAL OF EPIDEMIOLOGY (2023).
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