兰州大学机构库
Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau
2023-10-05
Source PublicationBMC BIOLOGY   Impact Factor & Quartile
ISSN1741-7007
EISSN1741-7007
Volume21Issue:1
page numbers14
AbstractBackground Domestication and introduction of dairy animals facilitated the permanent human occupation of the Tibetan Plateau. Yet the history of dairy pastoralism in the Tibetan Plateau remains poorly understood. Little is known how Tibetans adapted to milk and dairy products.Results We integrated archeological evidence and genetic analysis to show the picture that the dairy ruminants, together with dogs, were introduced from West Eurasia into the Tibetan Plateau since similar to 3600 years ago. The genetic admixture between the exotic and indigenous dogs enriched the candidate lactase persistence (LP) allele 10974A > G of West Eurasian origin in Tibetan dogs. In vitro experiments demonstrate that - 13838G > A functions as a LP allele in Tibetans. Unlike multiple LP alleles presenting selective signatures in West Eurasians and South Asians, the de novo origin of Tibetan-specific LP allele - 13838G > A with low frequency (similar to 6-7%) and absence of selection corresponds - 13910C > T in pastoralists across eastern Eurasia steppe.Conclusions Results depict a novel scenario of genetic and cultural adaptations to diet and expand current understanding of the establishment of dairy pastoralism in the Tibetan Plateau.
KeywordLactase persistence Tibetan Dog Selection Admixture Pastoralism
PublisherBMC
DOI10.1186/s12915-023-01707-x
Indexed BySCIE
Language英语
WOS Research AreaLife Sciences & Biomedicine - Other Topics
WOS SubjectBiology
WOS IDWOS:001078867600001
Original Document TypeArticle
PMID 37798721
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568265
Collection兰州大学
资源环境学院
Corresponding AuthorQi, Xue-Bin; Dong, Guanghui; Su, Bing; Zhang, Ya-Ping
Affiliation
1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China;
2.Chinese Acad Sci, Kunming Inst Zool, Yunnan Key Lab Mol Biol Domest Anim, Kunming 650223, Yunnan, Peoples R China;
3.Chinese Acad Sci, Kunming Inst Zool, KIZ CUHK Joint Lab Bioresources & Mol Res Common, Kunming 650223, Yunnan, Peoples R China;
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
5.Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China;
6.Chinese Acad Med Sci, Inst Med Biol, Peking Union Med Coll, Kunming 650118, Yunnan, Peoples R China;
7.Lanzhou Univ, Coll Earth & Environm Sci, Key Lab Western Chinas Environm Syst, Minist Educ, Lanzhou 730000, Peoples R China;
8.KUST, Sch Primate Translat Med, State Key Lab Primate Biomed Res LPBR, Kunming 650000, Yunnan, Peoples R China;
9.Tibetan Univ, High Altitude Med Res Ctr, Sch Med, Lhasa 850000, Peoples R China;
10.High Altitude Med Res Inst, Natl Key Lab High Altitude Med, Xining 810000, Peoples R China;
11.First Peoples Hosp Gansu Prov, Lanzhou 730000, Peoples R China;
12.Royal Ontario Museum, Ctr Biodivers & Conservat Biol, Toronto, ON M5S 2C6, Canada;
13.Tibetan Fukang Hosp, Lhasa 850000, Peoples R China
Corresponding Author AffilicationCollege of Earth Environmental Sciences
Recommended Citation
GB/T 7714
Peng, Min-Sheng,Liu, Yan-Hu,Shen, Quan-Kuan,et al. Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau[J]. BMC BIOLOGY,2023,21(1).
APA Peng, Min-Sheng.,Liu, Yan-Hu.,Shen, Quan-Kuan.,Zhang, Xiao-Hua.,Dong, Jiajia.,...&Zhang, Ya-Ping.(2023).Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau.BMC BIOLOGY,21(1).
MLA Peng, Min-Sheng,et al."Genetic and cultural adaptations underlie the establishment of dairy pastoralism in the Tibetan Plateau".BMC BIOLOGY 21.1(2023).
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