兰州大学机构库
The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway
Wang, Dan1,2,3; Deng, Bochuan4; Cheng, Lu5; Li, Jieru4; Guo, Xiaomin4; Zhang, Jiao4; Zhang, Xiang4; Su, Ping4; Li, Guofeng6; Miao, Xiaokang4; Yang, Wenle4; Xie, Junqiu4; Wang, Rui1,2,4
2023-11
Source PublicationFASEB JOURNAL   Impact Factor & Quartile
ISSN0892-6638 ; 1530-6860
EISSN1530-6860
Volume37Issue:11
page numbers15
AbstractPulmonary fibrosis (PF), which is caused by continuous alveolar epithelial cell injury and abnormal repair, is referred to as a difficult disease of the lung system by the World Health Organization due to its rapid progression, poor prognosis, and high mortality rate. However, there is still a lack of ideal therapeutic strategies. The peptide DR8 (DHNNPQIR-NH2), which is derived from rapeseed, exerted antifibrotic activity in the lung, liver, and kidney in our previous studies. By studying the structure-activity relationship and rational design, we introduced an unnatural hydrophobic amino acid (alpha-(4-pentenyl)-Ala) into DR8 and screened the novel peptide DR4penA (DHN alpha-(4-pentenyl)-APQIR-NH2), which had higher anti-PF activity, higher antioxidant activity and a longer half-life than DR8. Notably, DR4penA attenuated bleomycin- and paraquat-induced PF, and the anti-PF activity of DR4penA was equivalent to that of pirfenidone. Additionally, DR4penA suppressed the TGF-beta/Smad pathway in TGF-beta 1-induced A549 cells and paraquat-induced rats. This study demonstrates that the novel peptide DR4penA is a potential candidate compound for PF therapy, and its antifibrotic activity in different preclinical models of PF provides a theoretical basis for further study.
Keywordbleomycin paraquat peptide pulmonary fibrosis TGF-beta/Smad pathway
PublisherWILEY
DOI10.1096/fj.202301363R
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biology ; Cell Biology
WOS IDWOS:001085439600001
Original Document TypeArticle
PMID 37855708
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568372
Collection兰州大学
Corresponding AuthorXie, Junqiu; Wang, Rui
Affiliation
1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China;
2.Chinese Acad Med Sci & Peking Union Med Coll, Res Unit Peptide Sci, 1 Xian Nong Tan St, Beijing 100050, Peoples R China;
3.North Sichuan Med Coll, Med Imaging Key Lab Sichuan Prov, Nanchong, Peoples R China;
4.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China;
5.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen, Peoples R China;
6.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen, Peoples R China
Recommended Citation
GB/T 7714
Wang, Dan,Deng, Bochuan,Cheng, Lu,et al. The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway[J]. FASEB JOURNAL,2023,37(11).
APA Wang, Dan.,Deng, Bochuan.,Cheng, Lu.,Li, Jieru.,Guo, Xiaomin.,...&Wang, Rui.(2023).The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway.FASEB JOURNAL,37(11).
MLA Wang, Dan,et al."The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway".FASEB JOURNAL 37.11(2023).
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