兰州大学机构库
Personalised neoantigen-based therapy in colorectal cancer
Zhu, Ya-Juan1,2; Li, Xiong3; Chen, Ting-Ting4; Wang, Jia-Xiang5; Zhou, Yi-Xin1,2; Mu, Xiao-Li1,2; Du, Yang1,2; Wang, Jia-Ling1,2; Tang, Jie6; Liu, Ji-Yan1,2
2023-11
Source PublicationClinical and Translational Medicine   Impact Factor & Quartile
ISSN2001-1326
Volume13Issue:11
page numbers21
AbstractColorectal cancer (CRC) has become one of the most common tumours with high morbidity, mortality and distinctive evolution mechanism. The neoantigens arising from the somatic mutations have become considerable treatment targets in the management of CRC. As cancer-specific aberrant peptides, neoantigens can trigger the robust host immune response and exert anti-tumour effects while minimising the emergence of adverse events commonly associated with alternative therapeutic regimens. In this review, we summarised the mechanism, generation, identification and prognostic significance of neoantigens, as well as therapeutic strategies challenges of neoantigen-based therapy in CRC. The evidence suggests that the establishment of personalised neoantigen-based therapy holds great promise as an effective treatment approach for patients with CRC. Critical Points:Peptide vaccine and neoantigens pulsed DC can trigger a robust antitumor immune response with less emergence of adverse events than other therapeutic regimens.DNA vaccine can spontaneously induce T cell response against tumor and inhibit tumor growth with low cost.mRNA vaccines have been shown to safely induce neoantigen-specific T-cell responses without MHC haplotype restriction.Personalized immunotherapy based on neoantigens will be an effective treatments for patients with CRC.image
Keywordcancer vaccine colorectal cancer immunotherapy neoantigens targeted therapy
PublisherJOHN WILEY & SONS LTD
DOI10.1002/ctm2.1461
Indexed BySCIE
Language英语
WOS Research AreaOncology ; Research & Experimental Medicine
WOS SubjectOncology ; Medicine, Research & Experimental
WOS IDWOS:001092272300001
Original Document TypeReview
PMID 37921274
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568394
Collection兰州大学
Corresponding AuthorTang, Jie; Liu, Ji-Yan
Affiliation
1.Sichuan Univ, West China Hosp, Dept Biotherapy, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;
2.Sichuan Univ, West China Hosp, Canc Ctr, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;
3.Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Gastroenterol, Xian, Peoples R China;
4.Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;
5.Peking Univ, Canc Hosp & Inst, Dept Renal Canc & Melanoma, Beijing, Peoples R China;
6.Sichuan Univ, West China Hosp, Clin Trial Ctr, Chengdu, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Ya-Juan,Li, Xiong,Chen, Ting-Ting,et al. Personalised neoantigen-based therapy in colorectal cancer[J]. Clinical and Translational Medicine,2023,13(11).
APA Zhu, Ya-Juan.,Li, Xiong.,Chen, Ting-Ting.,Wang, Jia-Xiang.,Zhou, Yi-Xin.,...&Liu, Ji-Yan.(2023).Personalised neoantigen-based therapy in colorectal cancer.Clinical and Translational Medicine,13(11).
MLA Zhu, Ya-Juan,et al."Personalised neoantigen-based therapy in colorectal cancer".Clinical and Translational Medicine 13.11(2023).
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