兰州大学机构库
Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis
Tang, Xiaolong1,2; Yang, Lixia3; Miao, Yandong1,4; Ha, Wuhua1; Li, Zheng5; Mi, Denghai1,3
2023-10-03
Source PublicationBMC MICROBIOLOGY   Impact Factor & Quartile
ISSN1471-2180
Volume23Issue:1
page numbers16
AbstractBackground Angelica polysaccharides (AP) have numerous benefits in relieving type 2 diabetes (T2D). However, the underlying mechanisms have yet to be fully understood. Recent many reports have suggested that altering gut microbiota can have adverse effects on the host metabolism and contribute to the development of T2D. Here, we successfully established the T2D model using the male KKAy mice with high-fat and high-sugar feed. Meanwhile, the male C57BL/6 mice were fed with a normal feed. T2D KKAy mice were fed either with or without AP supplementation. In each group, we measured the mice's fasting blood glucose, weight, and fasting serum insulin levels. We collected the cecum content of mice, the gut microbiota was analyzed by targeted full-length 16S rRNA metagenomic sequencing and metabolites were analyzed by untargeted-metabolomics.Results We found AP effectively alleviated glycemic disorders of T2D KKAy mice, with the changes in gut microbiota composition and function. Many bacteria species and metabolites were markedly changed in T2D KKAy mice and reversed by AP. Additionally, 16 altered metabolic pathways affected by AP were figured out by combining metagenomic pathway enrichment analysis and metabolic pathway enrichment analysis. The key metabolites in 16 metabolic pathways were significantly associated with the gut microbial alteration. Together, our findings showed that AP supplementation could attenuate the diabetic phenotype. Significant gut microbiota and gut metabolite changes were observed in the T2D KKAy mice and AP intervention.Conclusions Administration of AP has been shown to improve the composition of intestinal microbiota in T2D KKAy mice, thus providing further evidence for the potential therapeutic application of AP in the treatment of T2D.
KeywordType 2 diabetes Gut microbiota Metagenomics Metabolomics 16S rRNA gene sequences
PublisherBMC
DOI10.1186/s12866-023-03029-y
Indexed BySCIE
Language英语
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:001081949800001
Original Document TypeArticle
PMID 37784018
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568468
Collection兰州大学
Corresponding AuthorMi, Denghai
Affiliation
1.Lanzhou Univ, Clin Med Coll 1, Lanzhou City, Gansu Province, Peoples R China;
2.North Sichuan Med Coll, Dept Gastrointestinal Surg 2, Affiliated Hosp, Nanchong City, Sichuan Provinc, Peoples R China;
3.Gansu Acad Tradit Chinese Med, Lanzhou City, Gansu Province, Peoples R China;
4.Binzhou Med Univ, Clin Med Coll 2, Dept Oncol, Dept Neurol,Yantai Affiliated Hosp, Yantai, Shandong Provin, Peoples R China;
5.Sichuan Univ, Canc Ctr, Dept Radiotherapy, West China Hosp, Chengdu, Sichuan Provinc, Peoples R China
Recommended Citation
GB/T 7714
Tang, Xiaolong,Yang, Lixia,Miao, Yandong,et al. Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis[J]. BMC MICROBIOLOGY,2023,23(1).
APA Tang, Xiaolong,Yang, Lixia,Miao, Yandong,Ha, Wuhua,Li, Zheng,&Mi, Denghai.(2023).Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis.BMC MICROBIOLOGY,23(1).
MLA Tang, Xiaolong,et al."Angelica polysaccharides relieve blood glucose levels in diabetic KKAy mice possibly by modulating gut microbiota: an integrated gut microbiota and metabolism analysis".BMC MICROBIOLOGY 23.1(2023).
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