兰州大学机构库
Doped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry
Wang, Chuang1,2,3; Qin, Lu-Yuan2,3; Li, Dong-Mei2,3,4,5; Hu, Li-Gang5; Xue, Jin-Juan2,3; Zhai, Xin-Ping6; Wang, Qiang6; Guo, Lei2,3; Tang, Li1; Xie, Jian-Wei2,3
2023-10-18
Online publication date2023-10
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN1618-2642 ; 1618-2650
EISSN1618-2650
Volume415Issue:27Pages:6825-6838
page numbers14
AbstractThis work aims to rapidly detect toxic alkaloids in traditional Chinese medicines (TCM) using laser desorption ionization mass spectrometry (LDI-MS). We systematically investigated twelve nanomaterials (NMs) as matrices and found that MoS2 and defect-rich-WO3 (D-WO3) were the best NMs for alkaloid detection. MoS2 and D-WO3 can be used directly as matrices dipped onto conventional ground steel target plates. Additionally, they can be conveniently fabricated as three-dimensional (3D) NM plates, where the MoS2 or D-WO3 NM is doped into resin and formed using a 3D printing process. We obtained good quantification of alkaloids using a chemothermal compound as an internal standard and detected related alkaloids in TCM extracts, Fuzi (Aconiti Lateralis Radix Praeparata), Caowu (Aconiti Kusnezoffii Radix), Chuanwu (Aconiti Radix), and Houpo (Magnoliae Officinalis Cortex). The work enabled the advantageous dip and measure method, demonstrating a simple and fast LDI-MS approach that achieves clean backgrounds for alkaloid detection. The 3D NM plates also facilitated mass spectrometry imaging of alkaloids in TCMs. This method has potential practical applications in medicine and food safety.Graphical AbstractDoped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry
KeywordAlkaloid Laser desorption ionization mass spectrometry 3D printing Nanomaterials Traditional Chinese medicines Mass spectrometry imaging
PublisherSPRINGER HEIDELBERG
DOI10.1007/s00216-023-04961-8
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:001084733100001
Original Document TypeArticle ; Early Access
PMID 37848578
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568476
Collection兰州大学
Corresponding AuthorWang, Qiang; Guo, Lei; Tang, Li
Affiliation
1.Minzu Univ China, Sch Pharm, Key Lab Ethnomed, Minist Educ, Beijing 100081, Peoples R China;
2.Acad Mil Med Sci, Inst Toxicol & Pharmacol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China;
3.Acad Mil Med Sci, Inst Toxicol & Pharmacol, Lab Toxicant Anal, Beijing 100850, Peoples R China;
4.Natl Antidrug Lab Beijing Reg Ctr, Beijing 100164, Peoples R China;
5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China;
6.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Wang, Chuang,Qin, Lu-Yuan,Li, Dong-Mei,et al. Doped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2023,415(27):6825-6838.
APA Wang, Chuang.,Qin, Lu-Yuan.,Li, Dong-Mei.,Hu, Li-Gang.,Xue, Jin-Juan.,...&Xie, Jian-Wei.(2023).Doped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,415(27),6825-6838.
MLA Wang, Chuang,et al."Doped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 415.27(2023):6825-6838.
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