兰州大学机构库
Protein target highlights in CASP15: Analysis of models by structure providers
2023-07-26
Online publication date2023-07
Source PublicationPROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS   Impact Factor & Quartile
ISSN0887-3585 ; 1097-0134
page numbers29
AbstractWe present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
KeywordCASP cryo-EM protein structure prediction X-ray crystallography
PublisherWILEY
DOI10.1002/prot.26545
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:001035776300001
Original Document TypeArticle ; Early Access
PMID 37493353
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568504
Collection兰州大学
Corresponding AuthorAlexander, Leila T.
Affiliation
1.Univ Basel, Biozentrum, Basel, Switzerland;
2.SIB Swiss Inst Bioinformat, Computat Struct Biol, Basel, Switzerland;
3.Univ Calif Davis, Genome Ctr, Davis, CA USA;
4.Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne, Switzerland;
5.Univ Milan, Dept Biosci, Milan, Italy;
6.IBBA CNR Unit Milano, Inst Agr Biol & Biotechnol, Milan, Italy;
7.NYU, Sch Med, Dept Cell Biol, New York, NY USA;
8.Univ Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France;
9.Univ Birmingham, Birmingham, England;
10.NYU, Sch Med, Dept Microbiol, New York, NY USA;
11.Univ Edinburgh, Inst Cell Biol, Wellcome Ctr Cell Biol, Edinburgh, Scotland;
12.Univ Michigan, Dept Biol Chem Computat Med & Bioinformat, Ann Arbor, MI USA;
13.Bielefeld Univ, Dept Chem, Bielefeld, Germany;
14.Monash Univ, Biomed Discovery Inst, Dept Microbiol, Clayton, Vic, Australia;
15.Monash Univ, Securing Antarcticas Environm Future, Clayton, Vic, Australia;
16.Monash Univ, Ctr Impact AMR, Clayton, Vic, Australia;
17.Monash Univ, ARC Res Hub Carbon Utilisat & Recycling, Clayton, Vic, Australia;
18.Univ Oxford, Wellcome Ctr Human Genet, Div Struct Biol, Oxford, England;
19.Monash Inst Pharmaceut Sci, Ctr Electron Microscopy Membrane Prot, Parkville, Vic, Australia;
20.Max Planck Inst Biol, Tubingen, Germany;
21.Univ Tubingen, Interfac Inst Biochem, Tubingen, Germany;
22.Univ Leicester, Leicester Inst Struct & Chem Biol, Dept Mol & Cell Biol, Leicester, England;
23.Univ Bergen, Dept Biomed, Bergen, Norway;
24.Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland;
25.Univ Oulu, Bioctr Oulu, Oulu, Finland;
26.ISPA CNR Unit Lecce, Inst Sci Food Prod, Lecce, Italy;
27.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA USA;
28.Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA USA;
29.Lanzhou Univ, Sch Life Sci, Lanzhou, Peoples R China;
30.Rice Univ, Dept Biosci, Houston, TX USA;
31.Northwestern Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL USA;
32.NanoTag Biotechnol GmbH, Gottingen, Germany;
33.Univ Gottingen, Inst Neuro & Sensory Physiol, Med Ctr, Gottingen, Germany;
34.Univ Gottingen, Ctr Biostruct Imaging Neurodegenerat BIN, Med Ctr, Gottingen, Germany;
35.Rice Univ, Dept Chem, Houston, TX USA;
36.Univ Nebraska, Dept Biochem, Lincoln, NE USA;
37.Univ Nebraska, Redox Biol Ctr, Lincoln, NE USA;
38.Rice Univ, Dept Bioengn, Houston, TX USA;
39.Univ Med Ctr Hamburg Eppendorf UKE, Hamburg, Germany;
40.Leibniz Inst Virol LIV, Ctr Struct Syst Biol, Hamburg, Germany;
41.Univ Maryland, Inst Biosci & Biotechnol Res, Dept Cell Biol & Mol Genet, Rockville, MD USA;
42.Univ Greifswald, Inst Biochem, Greifswald, Germany;
43.Univ New Mexico, Dept Mol Genet & Microbiol, Albuquerque, NM USA
Recommended Citation
GB/T 7714
Alexander, Leila T.,Durairaj, Janani,Kryshtafovych, Andriy,et al. Protein target highlights in CASP15: Analysis of models by structure providers[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2023.
APA Alexander, Leila T..,Durairaj, Janani.,Kryshtafovych, Andriy.,Abriata, Luciano A..,Bayo, Yusupha.,...&Schwede, Torsten.(2023).Protein target highlights in CASP15: Analysis of models by structure providers.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.
MLA Alexander, Leila T.,et al."Protein target highlights in CASP15: Analysis of models by structure providers".PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2023).
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