兰州大学机构库
MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products
Chan, Ka Iong1; Zhang, Siyuan1; Li, Guodong1; Xu, Yida1; Cui, Liao2; Wang, Yitao1; Su, Huanxing1,4; Tan, Wen3; Zhong, Zhangfeng1,4
2023-06-14
Online publication date2023-06
Source PublicationAging and Disease   Impact Factor & Quartile
ISSN2152-5250
page numbers58
AbstractVarious diseases, including cancers, age-associated disorders, and acute liver failure, have been linked to the oncogene, MYC. Animal testing and clinical trials have shown that sustained tumor volume reduction can be achieved when MYC is inactivated, and different combinations of therapeutic agents including MYC inhibitors are currently being developed. In this review, we first provide a summary of the multiple biological functions of the MYC oncoprotein in cancer treatment, highlighting that the equilibrium points of the MYC/MAX, MIZ1/MYC/MAX, and MAD (MNT)/MAX complexes have further potential in cancer treatment that could be used to restrain MYC oncogene expression and its functions in tumorigenesis. We also discuss the multifunctional capacity of MYC in various cellular cancer processes, including its influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, and intestinal flora. Moreover, we summarize the MYC therapy patent landscape and emphasize the potential of MYC as a druggable target, using herbal medicine modulators. Finally, we describe pending challenges and future perspectives in biomedical research, involving the development of therapeutic approaches to modulate MYC or its targeted genes. Patients with cancers driven by MYC signaling may benefit from therapies targeting these pathways, which could delay cancerous growth and recover antitumor immune responses.
KeywordMYC cancer immune response multidrug resistance natural product herbal medicine
PublisherINT SOC AGING & DISEASE
DOI10.14336/AD.2023.0520
Indexed BySCIE
Language英语
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:001017444500001
Original Document TypeReview ; Early Access
PMID 37450923
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568729
Collection兰州大学
Corresponding AuthorSu, Huanxing; Tan, Wen; Zhong, Zhangfeng
Affiliation
1.Univ Macau, Inst Chinese Med Sci, Macao Ctr Res & Dev Chinese Med, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;
2.Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Zhanjiang 524000, Peoples R China;
3.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;
4.Univ Macau, Inst Chinese Med Sci, Macau 999078, Peoples R China
Recommended Citation
GB/T 7714
Chan, Ka Iong,Zhang, Siyuan,Li, Guodong,et al. MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products[J]. Aging and Disease,2023.
APA Chan, Ka Iong.,Zhang, Siyuan.,Li, Guodong.,Xu, Yida.,Cui, Liao.,...&Zhong, Zhangfeng.(2023).MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products.Aging and Disease.
MLA Chan, Ka Iong,et al."MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products".Aging and Disease (2023).
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