兰州大学机构库
Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids
Yang, Pengfei1,2,3; Li, Jin1,2,4; Zhang, Tianyi1,2,3; Ren, Yanxian5; Zhang, Qiuning1,2; Liu, Ruifeng1,2; Li, Haining6; Hua, Junrui1,2; Wang, Wen-An5; Wang, Jufang1,2; Zhou, Heng1,2,3
2023-10-12
Online publication date2023-10
Source PublicationCELL DEATH AND DIFFERENTIATION   Impact Factor & Quartile
ISSN1350-9047 ; 1476-5403
EISSN1476-5403
page numbers14
AbstractFerroptosis is a type of cell death characterized by the accumulation of intracellular iron and an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related. Ionizing radiation is a frequently used cancer therapy to kill malignancies. We found that ionizing radiation induces both ferroptosis and autophagy and that there is a form of mutualism between the two processes. Ionizing radiation also causes lipid droplets to form in proximity to damaged mitochondria, which, through the action of mitophagy, results in the degradation of the peridroplet mitochondria by lysosomes and the consequent release of free fatty acids and a significant increase in lipid peroxidation, thus promoting ferroptosis. Ionizing radiation has a stronger, fatal effect on cells with a high level of mitophagy, and this observation suggests a novel strategy for tumor treatment.
PublisherSPRINGERNATURE
DOI10.1038/s41418-023-01230-0
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:001082725100002
Original Document TypeArticle ; Early Access
PMID 37828085
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568777
Collection兰州大学
第一临床医学院
Corresponding AuthorWang, Jufang; Zhou, Heng
Affiliation
1.Chinese Acad Sci, Inst Modern Phys, Key Lab Space Radiobiol Gansu Prov, Lanzhou, Peoples R China;
2.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Peoples R China;
3.Yangzhou Univ, Sch Publ Hlth, Yangzhou, Peoples R China;
4.Renmin Hosp Wuhan Econ & Technol Dev Zone, Wuhan, Peoples R China;
5.Lanzhou Univ, Hosp 1, Dept Gen Surg, Lanzhou, Peoples R China;
6.Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Sci, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Yang, Pengfei,Li, Jin,Zhang, Tianyi,et al. Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids[J]. CELL DEATH AND DIFFERENTIATION,2023.
APA Yang, Pengfei.,Li, Jin.,Zhang, Tianyi.,Ren, Yanxian.,Zhang, Qiuning.,...&Zhou, Heng.(2023).Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids.CELL DEATH AND DIFFERENTIATION.
MLA Yang, Pengfei,et al."Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids".CELL DEATH AND DIFFERENTIATION (2023).
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