兰州大学机构库
Efficacy of pterostilbene suppression on Aspergillus flavus growth, aflatoxin B1 biosynthesis and potential mechanisms
Hu, Yong-Mei1; Wang, Yi-Rong1; Zhao, Wen -Bin1; Ding, Yan Yan1; Wu, Zheng-Rong1; Wang, Guang-Han1; Deng, Peng1; Zhang, Shao-Yong2; An, Jun-Xia1; Zhang, Zhi-Jun1; Luo, Xiong-Fei1; Liu, Ying-Qian1,2,3
2023-11-02
Online publication date2023-07
Source PublicationINTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY   Impact Factor & Quartile
ISSN0168-1605 ; 1879-3460
Volume404
page numbers11
AbstractAspergillus flavus, a widespread saprotrophic filamentous fungus, could colonize agricultural crops with aflatoxin contamination, which endangers food security and the agricultural economy. A safe, effective and environ-mentally friendly fungicide is urgently needed. Pterostilbene, a natural phytoalexin originated from Pterocarpus indicus Willd., Vaccinium spp. and Vitis vinifera L., has been reported to possess excellent antimicrobial activity. More importantly, it is quite safe and healthy. In our screening tests of plant polyphenols for the inhibition of A. flavus, we found that pterostilbene evidently inhibited mycelial growth of Aspergillus flavus (EC50 = 15.94 & mu;g/ mL) and the inhibitory effect was better than that of natamycin (EC50 = 22.01 & mu;g/mL), which is a natural product widely used in food preservation. Therefore, we provided insights into the efficacy of pterostilbene suppression on A. flavus growth, aflatoxin B1 biosynthesis and its potential mechanisms against A. flavus in the present study. Here, pterostilbene at concentrations of 250 and 500 & mu;g/mL could effectively inhibit the infection of A. flavus on peanuts. And the biosynthesis of the secondary metabolite aflatoxin B1 was also inhibited. The antifungal effects of pterostilbene are exerted by inducing a large amount of intracellular reactive oxygen species production to bring the cells into a state of oxidative stress, damaging cellular biomolecules such as DNA, proteins and lipids and destroying the integrity of the cell membrane. Taken together, our study strongly supported the fact that pterostilbene could be considered a safe and effective antifungal agent against A. flavus infection.
KeywordPterostilbene Aspergillus flavus AflatoxinB1 Oxidative stress
PublisherELSEVIER
DOI10.1016/j.ijfoodmicro.2023.110318
Indexed BySCIE
Language英语
WOS Research AreaFood Science & Technology ; Microbiology
WOS SubjectFood Science & Technology ; Microbiology
WOS IDWOS:001044025000001
Original Document TypeArticle
PMID 37454507
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/568998
Collection兰州大学
Corresponding AuthorLiu, Ying-Qian
Affiliation
1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;
2.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China;
3.Lanzhou Univ, State Key Lab Grassland Agroecosystems, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Hu, Yong-Mei,Wang, Yi-Rong,Zhao, Wen -Bin,et al. Efficacy of pterostilbene suppression on Aspergillus flavus growth, aflatoxin B1 biosynthesis and potential mechanisms[J]. INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY,2023,404.
APA Hu, Yong-Mei.,Wang, Yi-Rong.,Zhao, Wen -Bin.,Ding, Yan Yan.,Wu, Zheng-Rong.,...&Liu, Ying-Qian.(2023).Efficacy of pterostilbene suppression on Aspergillus flavus growth, aflatoxin B1 biosynthesis and potential mechanisms.INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY,404.
MLA Hu, Yong-Mei,et al."Efficacy of pterostilbene suppression on Aspergillus flavus growth, aflatoxin B1 biosynthesis and potential mechanisms".INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY 404(2023).
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