兰州大学机构库
The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Liu, Xiaoming1; Zeng, Xuejiao1; Mahe, Jinli1; Guo, Kai1; He, Panpan1; Yang, Qianwen1; Zhang, Zhiwei1; Li, Zhongxia2; Wang, Di2; Zhang, Zheqing3; Wang, Lei4; Jing, Lipeng1
2023-10
Source PublicationNutrients   Impact Factor & Quartile
ISSN2072-6643
EISSN2072-6643
Volume15Issue:19
page numbers13
AbstractDyslipidemia, a condition implying high cardiovascular risks, has been widely studied on its potential nutrition interventions, including functional foods. This study aims to examine the effect of nattokinase monascus supplements (NMSs) on cardiovascular biomarkers and carotid intima-media thickness (CIMT) in patients with dyslipidemia. A total of 113 eligible subjects were randomly assigned to receive either NMSs or a placebo (55 and 58, respectively). After a 120-day intervention, there were significant mean absolute changes in total cholesterol (TC), low-density cholesterol (LDL-C), non-high-density cholesterol (non-HDL-C), and low-density cholesterol to high-density cholesterol ratio (LDL-C to HDL-C ratio), with values of -0.52 (95% CI: -0.51 to -0.54) mmol/L, -0.43 (95% CI: -0.45 to -0.41) mmol/L, -0.52 (95% CI: -0.52 to -0.52) mmol/L, and -0.29 (95% CI: -0.30 to -0.28) mmol/L, respectively, between the two groups. However, no significant differences were found in triglycerides (TGs), high-density cholesterol (HDL-C), and CIMT. Furthermore, the results for lipids and CIMT remained essentially unchanged after adjusting for various confounding factors using the analysis of covariance model. There were no significant differences in coagulation, liver function, renal function, or other indicators. No intervention-related adverse events, such as mouth ulcers, drooling, and stomach pain, were reported. The study results demonstrate that NMSs can ameliorate lipid levels (TC, LDL-C, non-HDL-C, and the LDL-C to HDL-C ratio) without the occurrence of adverse events. However, it did not significantly affect serum TG, HDL-C, and CIMT.
Keyworddyslipidemia lovastatin nattokinase red yeast rice nattokinase-monascus supplements
PublisherMDPI
DOI10.3390/nu15194239
Indexed BySCIE
Language英语
WOS Research AreaNutrition & Dietetics
WOS SubjectNutrition & Dietetics
WOS IDWOS:001085588700001
Original Document TypeArticle
PMID 37836525
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569039
Collection兰州大学
Corresponding AuthorWang, Lei; Jing, Lipeng
Affiliation
1.Lanzhou Univ, Inst Epidemiol & Stat, Sch Publ Hlth, Lanzhou 730000, Peoples R China;
2.BYHEALTH Inst Nutr & Hlth, 3 Kehui 3rd St,99 Kexue Ave Cent, Guangzhou 510663, Peoples R China;
3.Southern Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Peoples R China;
4.Lanzhou Univ, Dept Neurol, Hosp 2, Lanzhou 730030, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiaoming,Zeng, Xuejiao,Mahe, Jinli,et al. The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial[J]. Nutrients,2023,15(19).
APA Liu, Xiaoming.,Zeng, Xuejiao.,Mahe, Jinli.,Guo, Kai.,He, Panpan.,...&Jing, Lipeng.(2023).The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Nutrients,15(19).
MLA Liu, Xiaoming,et al."The Effect of Nattokinase-Monascus Supplements on Dyslipidemia: A Four-Month Randomized, Double-Blind, Placebo-Controlled Clinical Trial".Nutrients 15.19(2023).
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