兰州大学机构库
Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino-Aldehyde condensation strategy
Ma, Yue1; Zhou, Han1; Wang, Yi-Rong1; Zhang, Bao-Qi1; Zhang, Zhi-Jun1; Peng, Deng1; An, Jun-Xia1; Zhang, Shao-Yong2; Luo, Xiong-Fei1; Wang, Guang-Han1; Ding, Yan-Yan1; Zhao, Wen-Bin1; Hu, Yong-Mei1; Liu, Ying-Qian1,2,3
2023-10-03
Online publication date2023-10
Source PublicationPEST MANAGEMENT SCIENCE   Impact Factor & Quartile
ISSN1526-498X ; 1526-4998
EISSN1526-4998
page numbers12
AbstractBACKGROUND: Chemical fungicides are the mainstay of plant disease control in agricultural production, but there are a very limited number of drugs that can effectively control plant diseases. Two series of secondary amine derivatives were synthesized using the diamine skeleton combined with saturated aromatic and aliphatic aldehydes, and their antibacterial and antifungal activities against plant pathogens were determined. In addition, the antimicrobial mechanism of the highly active compound A26 was preliminarily examined against Xanthomonas oryzae (Xoo). RESULTS: Compound A26 exhibited the highest antibacterial potency among all the target compounds, with MIC values of 3.12, 3.12 and 12.5 mu g mL(-1) against Xoo, Xanthomonas axonopodis pv. Citri and Pseudomonas sollamacearum, respectively. In addition, compound A26 had powerful curative and protective effects against Xoo at 200 mu g mL(-1), and was better than the control agent Xinjunan. Preliminary mechanistic studies showed that compound A26 reduced the bacterial pathogenicity by targeting cell membranes and inhibiting the secretion of extracellular polysaccharides. Meanwhile, the toxicity of compound A26 to Human Embryonic Kidney 293 cells and Human Liver-7702 was similar to that of Xinjunan, and it had moderate toxicity according to the World Health Organization classification standard of oral exogenous toxicity, with an LD50 of 245.47 mg kg(-1). CONCLUSION: Secondary amines have efficient and broad-spectrum antibacterial activity against plant pathogenic bacteria and are expected to be a new class of candidate compounds for antibacterial drugs. (c) 2023 Society of Chemical Industry.
Keywordamines aldehydes antibacterial activity Xanthomonas oryzae mechanism of action
PublisherJOHN WILEY & SONS LTD
DOI10.1002/ps.7742
Indexed BySCIE
Language英语
WOS Research AreaAgriculture ; Entomology
WOS SubjectAgronomy ; Entomology
WOS IDWOS:001075990600001
Original Document TypeArticle ; Early Access
PMID 3761526
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569045
Collection兰州大学
Corresponding AuthorLiu, Ying-Qian
Affiliation
1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;
2.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou, Peoples R China;
3.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yue,Zhou, Han,Wang, Yi-Rong,et al. Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino-Aldehyde condensation strategy[J]. PEST MANAGEMENT SCIENCE,2023.
APA Ma, Yue.,Zhou, Han.,Wang, Yi-Rong.,Zhang, Bao-Qi.,Zhang, Zhi-Jun.,...&Liu, Ying-Qian.(2023).Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino-Aldehyde condensation strategy.PEST MANAGEMENT SCIENCE.
MLA Ma, Yue,et al."Short pathways to highly active antimicrobial: structurally diverse polyamines derivatives from Amino-Aldehyde condensation strategy".PEST MANAGEMENT SCIENCE (2023).
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