兰州大学机构库
Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses
Ma, Yue1; He, Ying-Hui1; Deng, Peng1; Zhang, Shao-Yong2; Ding, Yan-Yan1,2; Zhang, Zhi-Jun1; Zhang, Bao-Qi1; An, Jun-Xia1; Wang, Yi-Rong1; Liu, Ying-Qian1,3
2023-10-27
Online publication date2023-10
Source PublicationCHEMISTRY & BIODIVERSITY   Impact Factor & Quartile
ISSN1612-1872 ; 1612-1880
EISSN1612-1880
page numbers8
AbstractBased on the research strategy of drug repurposing, a series of derivatives and marketed drugs that containing salicylic acid skeleton were tested for their antibacterial activities against phytopathogens. Salicylic acid can not only regulate some important growth metabolism of plants, but also induce plant disease resistance. The bioassay results showed that the salicylamides exhibited excellent antibacterial activity. Especially, oxyclozanide showed the best antibacterial effect against Xanthomonas oryzae, Xanthomonas axonopodis pv. citri and Pectobacterium atroseptica with MICs of 0.78, 3.12 and 12.5 mu g.mL-1, respectively. In vivo experiments with rice bacterial leaf blight had further demonstrated that oxyclozanide exhibited stronger antibacterial activity than the commercial bactericide, thiodiazole copper. Oxyclozanide could induce plant defense responses through the determination of salicylic acid content and the activities of defense-related enzymes including CAT, POD, and SOD in rice. The preliminarily antibacterial mechanism study indicated that oxyclozanide exhibited the antibacterial activity by disrupting cell integrity and reducing bacterial pathogenicity. Additionally, oxyclozanide could induce plant defense responses through the determination of salicylic acid content. +image
Keywordrepurpose drugs salicylamide phytopathogenic bacteria mechanism defense response
PublisherWILEY-V C H VERLAG GMBH
DOI10.1002/cbdv.202300998
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:001088171600001
Original Document TypeArticle ; Early Access
PMID 3775507
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569089
Collection兰州大学
Corresponding AuthorLiu, Ying-Qian
Affiliation
1.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China;
2.Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China;
3.Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yue,He, Ying-Hui,Deng, Peng,et al. Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses[J]. CHEMISTRY & BIODIVERSITY,2023.
APA Ma, Yue.,He, Ying-Hui.,Deng, Peng.,Zhang, Shao-Yong.,Ding, Yan-Yan.,...&Liu, Ying-Qian.(2023).Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses.CHEMISTRY & BIODIVERSITY.
MLA Ma, Yue,et al."Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses".CHEMISTRY & BIODIVERSITY (2023).
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