兰州大学机构库
Yak milk protects against alcohol-induced liver injury in rats
Wang, Man1; Jiang, Yanshi2; Wang, Siying1; Fu, Lin1; Liang, Zujin1; Zhang, Ying1; Huang, Xiaodan1; Li, Xin1; Feng, Meiying1; Long, Danfeng1
2023-10-30
Online publication date2023-10
Source PublicationFood & Function   Impact Factor & Quartile
ISSN2042-6496 ; 2042-650X
EISSN2042-650X
Volume14Issue:21Pages:9857-9871
page numbers15
AbstractThe protective effects of yak milk (YM) against chronic alcoholic liver injury in rats were investigated in this study. Histologic and biochemical analyses demonstrated that YM consumption ameliorates alcohol-induced liver injury by increasing the liver antioxidant enzyme activity and reducing inflammation. Furthermore, microbiome and metabolomic analyses exploring YM's impact on gut microbiota and metabolism found that YM administration regulates gut microbiota composition. Specifically, there was a decrease in the relative abundance of Helicobacter, Streptococcus, Peptococcus and Tyzzerella, along with an increase in Turisibacter and Intestinimonas. Moreover, Pearson analysis indicated positive correlations between Peptococcus and Tyzzerella with ALT and AST levels, while showing a negative correlation with ADH levels. Furthermore, differential metabolite analysis of fecal samples from the YM group identified significant increases in the taurine (2-Aminoethanesulfonic acid), hypotaurine (2-Aminoethanesulfonic Acid) and isethionic acid levels. Finally, KEGG topology analysis highlighted taurine and hypotaurine metabolism as the primary pathways influenced by YM intervention. Therefore, these findings collectively suggest that YM may protect alcohol-exposed rats against liver injury by modulating oxidative stress, inflammatory response, gut microbiota disorder, and metabolic regulation.
PublisherROYAL SOC CHEMISTRY
DOI10.1039/d3fo03675h
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Food Science & Technology
WOS SubjectBiochemistry & Molecular Biology ; Food Science & Technology
WOS IDWOS:001085662200001
Original Document TypeArticle
PMID 37853817
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569114
Collection兰州大学
Corresponding AuthorLong, Danfeng
Affiliation
1.Lanzhou Univ, Sch Publ Hlth, Lanzhou, Peoples R China;
2.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin, Peoples R China
Recommended Citation
GB/T 7714
Wang, Man,Jiang, Yanshi,Wang, Siying,et al. Yak milk protects against alcohol-induced liver injury in rats[J]. Food & Function,2023,14(21):9857-9871.
APA Wang, Man.,Jiang, Yanshi.,Wang, Siying.,Fu, Lin.,Liang, Zujin.,...&Long, Danfeng.(2023).Yak milk protects against alcohol-induced liver injury in rats.Food & Function,14(21),9857-9871.
MLA Wang, Man,et al."Yak milk protects against alcohol-induced liver injury in rats".Food & Function 14.21(2023):9857-9871.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Wang, Man]'s Articles
[Jiang, Yanshi]'s Articles
[Wang, Siying]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Man]'s Articles
[Jiang, Yanshi]'s Articles
[Wang, Siying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Man]'s Articles
[Jiang, Yanshi]'s Articles
[Wang, Siying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.