兰州大学机构库
Probiotics, prebiotics, and postbiotics in health and disease
Ji, Jing1; Jin, Weilin2; Liu, Shuang-Jiang3; Jiao, Zuoyi4; Li, XK(李祥锴)1
2023-12
Source PublicationMEDCOMM   Impact Factor & Quartile
ISSN2688-2663
EISSN2688-2663
Volume4Issue:6
page numbers23
AbstractThe gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the gut microbiota, current traditional medicines can only relieve symptoms, and it is difficult to solve the root causes or even cause side effects like disturbances in the gut microbiota. Increasing clinical studies and evidences have demonstrated that probiotics, prebiotics, and postbiotics can prevent and treat various diseases, but currently they can only be used as dietary supplements rather than medicines, which restricts the application of probiotics in the field of medicine. Here, this review analyzes the importance of gut microbiota in human health and the current problems of traditional medicines, and systematically summarizes the effectiveness and mechanisms of probiotics, prebiotics, and postbiotics in maintaining health and treating diseases based on animal models and clinical trials. And based on current research outcomes and development trends in this field, the challenges and prospects of their clinical application in maintaining health, alleviating and treating diseases are analyzed. It is hoped to promote the application of probiotics, prebiotics, and postbiotics in disease treatment and open up new frontiers in probiotic research. Extensive research and clinical evidence have demonstrated the mechanisms and effectiveness of probiotics, prebiotics, and postbiotics in restoring gut microbiota homeostasis and treating a variety of diseases. Prebiotics can promote the growth of beneficial intestinal bacteria, while probiotics produce postbiotics through addition to regulate the gut microbiota, and subtraction to remove harmful metabolites and exogenous substances to reduce their impact on the body, thereby alleviating or treating diseases. Probiotics, prebiotics, and postbiotics may represent the next generation of medicines, with the potential to revolutionize the way we treat and manage disease.#image
Keywordclinical trials gut microbiota postbiotics prebiotics probiotics
PublisherWILEY
DOI10.1002/mco2.420
Indexed ByESCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:001092937300001
Original Document TypeReview
PMID 37929014
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569140
Collection兰州大学
生命科学学院
第一临床医学院
第二临床医学院
Corresponding AuthorLiu, Shuang-Jiang; Jiao, Zuoyi; Li, Xiangkai
Affiliation
1.Lanzhou Univ, Sch Life Sci, MOE Key Lab Cell Act & Stress Adaptat, Lanzhou, Gansu, Peoples R China;
2.Lanzhou Univ, Clin Med Coll 1, Med Frontier Innovat Res Ctr, Inst Canc Neurosci,Hosp 1, Lanzhou, Gansu, Peoples R China;
3.Chinese Acad Sci, State Key Lab Microbial Resources, Inst Microbiol, Beijing, Peoples R China;
4.Lanzhou Univ, Cuiying Biomed Res Ctr, Hosp 2, Lanzhou, Gansu, Peoples R China
First Author AffilicationSchool of Life Sciences
Corresponding Author AffilicationSecond Clinical School;  School of Life Sciences
Recommended Citation
GB/T 7714
Ji, Jing,Jin, Weilin,Liu, Shuang-Jiang,et al. Probiotics, prebiotics, and postbiotics in health and disease[J]. MEDCOMM,2023,4(6).
APA Ji, Jing,Jin, Weilin,Liu, Shuang-Jiang,Jiao, Zuoyi,&Li, Xiangkai.(2023).Probiotics, prebiotics, and postbiotics in health and disease.MEDCOMM,4(6).
MLA Ji, Jing,et al."Probiotics, prebiotics, and postbiotics in health and disease".MEDCOMM 4.6(2023).
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