兰州大学机构库
EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway
Wang, Hongyu1; Han, Ruiqin2; Li, Qiao1,3; Kang, Wei3; Dong, Qiang3; Yin, Hang1,3; Niu, Liang1,3; Dai, Junqiang3; Yan, Yunji1; Su, Yuanping1; Yao, Xuan1; Zhang, He1,3; Yuan, Guoqiang1,3,4,5; Pan, Yawen1,3,4,5
2023-11
Online publication date2023-08
Source PublicationMOLECULAR CARCINOGENESIS   Impact Factor & Quartile
ISSN0899-1987 ; 1098-2744
Volume62Issue:11Pages:1731-1744
page numbers14
AbstractThe cell cycle, a pivotal regulator of cell proliferation, can be significantly influenced by the phosphatase and tensin homolog (PTEN)/AKT signaling pathway's modulation of cyclin-related proteins. In our study, we discovered the crucial role of EEF1E1 in this process, as it appears to downregulate PTEN expression. Furthermore, our findings affirmed that EEF1E1 modulates downstream cell cycle-related proteins by suppressing the PTEN/AKT pathway. Cell cycle assay results revealed that EEF1E1 downregulation stunted the advancement of glioma cells in both the G1 and S phases. A suite of assays-Cell Counting Kit-8, colony formation, and ethyl-2'-deoxyuridine-substantiated that the EEF1E1 downregulation markedly curtailed glioma proliferation. We further validated this phenomenon through animal studies and coculture experiments on brain slices. Our comprehensive investigation indicates that EEF1E1 knockdown can effectively inhibit the glioma cell proliferation by regulating the cell cycle via the PTEN/AKT signaling pathway. Consequently, EEF1E1 emerges as a potential therapeutic target for glioma treatment, signifying critical clinical implications.
Keywordcell cycle cell proliferation glioma PTEN
PublisherWILEY
DOI10.1002/mc.23611
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Oncology
WOS SubjectBiochemistry & Molecular Biology ; Oncology
WOS IDWOS:001050971500001
Original Document TypeArticle
PMID 37589446
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569189
Collection兰州大学
Corresponding AuthorYuan, Guoqiang; Pan, Yawen
Affiliation
1.Lanzhou Univ, Med Coll 2, Lanzhou, Gansu, Peoples R China;
2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing, Peoples R China;
3.Lanzhou Univ, Hosp 2, Dept Neurosurg, Lanzhou, Gansu, Peoples R China;
4.Lanzhou Univ, Key Lab Neurol Gansu Prov, Lanzhou, Gansu, Peoples R China;
5.Lanzhou Univ, Hosp 2, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Wang, Hongyu,Han, Ruiqin,Li, Qiao,et al. EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway[J]. MOLECULAR CARCINOGENESIS,2023,62(11):1731-1744.
APA Wang, Hongyu.,Han, Ruiqin.,Li, Qiao.,Kang, Wei.,Dong, Qiang.,...&Pan, Yawen.(2023).EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway.MOLECULAR CARCINOGENESIS,62(11),1731-1744.
MLA Wang, Hongyu,et al."EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway".MOLECULAR CARCINOGENESIS 62.11(2023):1731-1744.
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