兰州大学机构库
IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China
Sun, Xudong1; Zhao, Shijun2; Zhang, Fuhua3; He, Lili1; Zhang, Jinhua3; Li, Xiaohua2; Wang, Li1; Jing, Tao1; Zhou, Yongning4; Han, Jian1
2023-12-31
Source PublicationAll Life   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
ISSN2689-5293 ; 2689-5307
Volume16Issue:1
page numbers9
AbstractPrevious studies revealed that both Helicobacter pylori infection and some cytokine gene polymorphisms are risk factors for gastric diseases. The association between H. pylori and gene polymorphisms is worth exploring. Here we conducted a case-control study and systematically evaluate on association between H. pylori infection and IL4, TNFA, and IL10 polymorphisms in a Chinese Han population in northwestern China, where gastric cancer is the major burden on the health and the leading cause of death in local community. The Sequenom MassArray platform was used to screen the genotypes and C-14-urea breath test was employed to determine H. pylori infection status of 705 participants of the local rural residents. Significant association between H. pylori infection and the IL4 rs34142320 polymorphism was observed in the dominant model (OR = 0.57, 95% CI = 0.40-0.80, P = 0.030). No significant association was found between IL4 rs2243250, TNFA rs1800630, TNFA rs1800629, TNFA rs1799964, IL10 rs1800871, IL10 rs1800896 and H. pylori infection. Haplotype analysis showed that T-DEL and G-C haplotypes of the observed IL4 SNPs were significantly associated with H. pylori infection. Our analysis demonstrated that the IL4 rs34142320 polymorphism has a protective effect on H. pylori infection in Chinese Han population.
KeywordHelicobacter pylori interleukin polymorphism infection case-control study
PublisherTAYLOR & FRANCIS LTD
DOI10.1080/26895293.2023.2236311
Indexed BySCIE
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:001040024400001
Original Document TypeArticle
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569222
Collection兰州大学
Corresponding AuthorZhou, Yongning; Han, Jian
Affiliation
1.Lanzhou Univ, Sch Basic Med Sci, Dept Pathogen Biol, Lanzhou, Peoples R China;
2.Wuwei Liangzhou Hosp, Dept Gastroenterol, Wuwei, Peoples R China;
3.Northwest Minzu Univ, Affiliated Hosp, Dept Gastroenterol, Lanzhou, Peoples R China;
4.Lanzhou Univ, Hosp 1, Dept Gastroenterol, Lanzhou, Peoples R China
First Author AffilicationSchool of Basic Medical Sciences
Corresponding Author AffilicationFirst Clinical School;  School of Basic Medical Sciences
First Signature AffilicationSchool of Basic Medical Sciences
Recommended Citation
GB/T 7714
Sun, Xudong,Zhao, Shijun,Zhang, Fuhua,et al. IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China[J]. All Life,2023,16(1).
APA Sun, Xudong.,Zhao, Shijun.,Zhang, Fuhua.,He, Lili.,Zhang, Jinhua.,...&Han, Jian.(2023).IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China.All Life,16(1).
MLA Sun, Xudong,et al."IL4 rs34142320 polymorphism is associated with susceptibility to Helicobacter pylori infection in Chinese Han population in northwestern China".All Life 16.1(2023).
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