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A Flexible Bivalent Approach to Comprehensively Improve the Performances of Stilbazolium Dyes as Amyloid-β Fluorescent Probes
Zhuang, Zi-Min1; Zhou, Zhe3; Chen, Xian2; Xu, Xin-Ru1; Wang, Hang-Xing1; Pan, Jie1,2
2023-09-18
Online publication date2023-09
Source PublicationACS Applied Materials & Interfaces   Impact Factor & Quartile
ISSN1944-8244 ; 1944-8252
EISSN1944-8252
Volume15Issue:38Pages:44742-44751
page numbers10
AbstractExploring new ways to reconstruct the structure and function of inappropriate organic fluorophores for improving amyloid-beta (A beta) fluorescent imaging performance is desired for precise detection and early diagnosis of Alzheimer's disease (AD). With stilbazolium dyes as examples, here, we present a multipronged approach to comprehensively improved the A beta fluorescent imaging performance through a flexible bivalent method, where a flexible carbon chain was introduced to link two monomers to form a homodimer. Our results reveal a mechanism wherein the flexible linker creates a well-defined probe with specific orientations and distinct photophysical properties. Applying this approach in combination with theoretical simulation, the homodimers exhibited a comprehensive improvement of the A beta fluorescent imaging performance of the dye monomers, including better photostability and higher signal-to-noise (S/N) ratio, higher off-on near-infrared fluorescence (NIRF) response sensitivity, higher specificity and affinity to A beta deposits, and more reasonable lipophilicity for blood-brain barrier (BBB) penetrability. The results demonstrate that flexible homodimers offer a multipronged approach to obtaining high-performance NIRF imaging reagents for the detection of A beta deposits both in vitro and in vivo.
Keywordflexible homodimer near-infrared fluorescence stilbazolium dyes protein aggregation amyloid-beta protein in vivo imaging
PublisherAMER CHEMICAL SOC
DOI10.1021/acsami.3c09034
Indexed BySCIE
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:001068654600001
Original Document TypeArticle
PMID 37721982
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569260
Collection兰州大学
Corresponding AuthorWang, Hang-Xing; Pan, Jie
Affiliation
1.Hubei Univ, Coll Chem & Chem Engn, Key Lab Synth & Applicat Organ Funct Mol, MOE, Wuhan 430062, Peoples R China;
2.Hubei Univ, Coll Hlth Sci & Engn, Wuhan 430062, Peoples R China;
3.Lanzhou Univ, Dept Obstet & Gynecol, First Hosp, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Zhuang, Zi-Min,Zhou, Zhe,Chen, Xian,et al. A Flexible Bivalent Approach to Comprehensively Improve the Performances of Stilbazolium Dyes as Amyloid-β Fluorescent Probes[J]. ACS Applied Materials & Interfaces,2023,15(38):44742-44751.
APA Zhuang, Zi-Min,Zhou, Zhe,Chen, Xian,Xu, Xin-Ru,Wang, Hang-Xing,&Pan, Jie.(2023).A Flexible Bivalent Approach to Comprehensively Improve the Performances of Stilbazolium Dyes as Amyloid-β Fluorescent Probes.ACS Applied Materials & Interfaces,15(38),44742-44751.
MLA Zhuang, Zi-Min,et al."A Flexible Bivalent Approach to Comprehensively Improve the Performances of Stilbazolium Dyes as Amyloid-β Fluorescent Probes".ACS Applied Materials & Interfaces 15.38(2023):44742-44751.
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