兰州大学机构库
p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy
Yang, Kaixin1; Xiao, Yinan1; Zhong, Linghui1; Zhang, Wenyang1; Wang, Peng2; Ren, Yaru1; Shi, Lei1
2023-11
Online publication date2023-09
Source PublicationCANCER GENE THERAPY   Impact Factor & Quartile
ISSN0929-1903 ; 1476-5500
Volume30Issue:11Pages:1456-1470
page numbers15
AbstractLong non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein modification and RNA-protein complexes. LncRNA dysregulation is frequently associated with a variety of biological functions and human diseases including cancer. The p53 network is a key tumor-suppressive mechanism that transcriptionally activates target genes to suppress cellular proliferation in human malignancies. Recent research indicates that lncRNAs play an important role in the p53 signaling pathway. In this review, we summarize the current knowledge of lncRNAs in p53-relevant functions and provide an overview of how these altered lncRNAs contribute to tumor initiation and progression. We also discuss the association between lncRNA and up- or downstream genes of p53. These findings imply that lncRNAs can help identify cellular vulnerabilities that may prove to be promising potential biomarkers and therapeutic targets for cancer treatment.
PublisherSPRINGERNATURE
DOI10.1038/s41417-023-00662-7
Indexed BySCIE
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
WOS IDWOS:001060730000003
Original Document TypeReview
PMID 37679529
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569285
Collection兰州大学
Corresponding AuthorShi, Lei
Affiliation
1.Lanzhou Univ, Sch Publ Hlth, RNA Oncol Grp, Lanzhou 730000, Peoples R China;
2.Hebei North Univ, Coll Anim Sci & Technol, Zhangjiakou 075131, Peoples R China
Recommended Citation
GB/T 7714
Yang, Kaixin,Xiao, Yinan,Zhong, Linghui,et al. p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy[J]. CANCER GENE THERAPY,2023,30(11):1456-1470.
APA Yang, Kaixin.,Xiao, Yinan.,Zhong, Linghui.,Zhang, Wenyang.,Wang, Peng.,...&Shi, Lei.(2023).p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy.CANCER GENE THERAPY,30(11),1456-1470.
MLA Yang, Kaixin,et al."p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy".CANCER GENE THERAPY 30.11(2023):1456-1470.
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