兰州大学机构库
Effects of long-term metal exposure on the structure and co-occurrence patterns of the oral microbiota of residents around a mining area
Pei, Shuwei1; Feng, Lu2; Zhang, Yonghua3; Liu, Jiangyun1; Li, Jia1; Zheng, Qiwen1; Liu, Xingrong1; Luo, Bin1; Ruan, Ye1; Li, Huan1; Hu, Weigang4; Niu, Jingping1; Tian, Tian1
2023-10-19
Source PublicationFrontiers in Microbiology   Impact Factor & Quartile
ISSN1664-302X
EISSN1664-302X
Volume14
page numbers15
AbstractObjectivesThe aim of our study was to investigate the impact of long-term exposure to heavy metals on the microbiome of the buccal mucosa, to unveil the link between environmental contamination and the oral microbial ecosystem, and to comprehend its potential health implications.MethodsSubjects were divided into two groups: the exposure group and the control group. We collected samples of buccal mucosa, soil, and blood, and conducted microbial diversity analysis on both groups of oral samples using 16S rRNA gene sequencing. The concentrations of heavy metals in blood and soil samples were also determined. Additionally, microbial networks were constructed for the purpose of topological analysis.ResultsDue to long-term exposure to heavy metals, the relative abundance of Rhodococcus, Delftia, Fusobacterium, and Peptostreptococcus increased, while the abundance of Streptococcus, Gemella, Prevotella, Granulicatella, and Porphyromonas decreased. The concentrations of heavy metals in the blood (Pb, Cd, Hg, and Mo) were associated with the growth of Rhodococcus, Delftia, Porphyromonas, and Gemella. In addition, the relative abundances of some pathogenic bacteria, such as Streptococcus anginosus, S. gordonii, and S. mutans, were found to be enriched in the exposure group. Compared to the exposure group network, the control group network had a greater number of nodes, modules, interactive species, and keystone taxa. Module hubs and connectors in the control group converted into peripherals in the exposure group, indicating that keystone taxa changed. Metals in the blood (Pb, Cd, Hg, and Mo) were drivers of the microbial network of the buccal mucosa, which can have adverse effects on the network, thus providing conditions for the occurrence of certain diseases.ConclusionLong-term exposure to multiple metals perturbs normal bacterial communities in the buccal mucosa of residents in contaminated areas. This exposure reduces the complexity and stability of the microbial network and increases the risk of developing various diseases.
Keywordheavy metal buccal mucosa bacteria keystone taxa network analysis 16S rRNA gene sequencing
PublisherFRONTIERS MEDIA SA
DOI10.3389/fmicb.2023.1264619
Indexed BySCIE
Language英语
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:001091849800001
Original Document TypeArticle
PMID 37928665
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569287
Collection兰州大学
Corresponding AuthorNiu, Jingping; Tian, Tian
Affiliation
1.Lanzhou Univ, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;
2.Lanzhou Univ, Sch Stomatol, Lanzhou, Gansu, Peoples R China;
3.Lanzhou Maternal & Child Hlth Care Hosp, Child Hlth Dept, Lanzhou, Gansu, Peoples R China;
4.Lanzhou Univ, Coll Ecol, State Key Lab Herbage Improvement & Grassland Agro, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Pei, Shuwei,Feng, Lu,Zhang, Yonghua,et al. Effects of long-term metal exposure on the structure and co-occurrence patterns of the oral microbiota of residents around a mining area[J]. Frontiers in Microbiology,2023,14.
APA Pei, Shuwei.,Feng, Lu.,Zhang, Yonghua.,Liu, Jiangyun.,Li, Jia.,...&Tian, Tian.(2023).Effects of long-term metal exposure on the structure and co-occurrence patterns of the oral microbiota of residents around a mining area.Frontiers in Microbiology,14.
MLA Pei, Shuwei,et al."Effects of long-term metal exposure on the structure and co-occurrence patterns of the oral microbiota of residents around a mining area".Frontiers in Microbiology 14(2023).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Pei, Shuwei]'s Articles
[Feng, Lu]'s Articles
[Zhang, Yonghua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Pei, Shuwei]'s Articles
[Feng, Lu]'s Articles
[Zhang, Yonghua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Pei, Shuwei]'s Articles
[Feng, Lu]'s Articles
[Zhang, Yonghua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.