兰州大学机构库
The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases
Wang, Yuqin1; Li, Yongnan2; Ding, Hong3; Li, Dan1; Shen, Wanxi4; Zhang, Xiaowei3
2023-09
Source PublicationJournal of Cardiovascular Development and Disease   Impact Factor & Quartile
ISSN2308-3425
Volume10Issue:9
page numbers25
AbstractSirtuins belong to the class III histone deacetylases and possess nicotinamide adenine dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases. Autophagy is a crucial adaptive cellular response to stress stimuli. Mounting evidence suggests a strong correlation between Sirtuins and autophagy, potentially involving cross-regulation and crosstalk. Sirtuin-mediated autophagy plays a crucial regulatory role in some cardiovascular diseases, including atherosclerosis, ischemia/reperfusion injury, hypertension, heart failure, diabetic cardiomyopathy, and drug-induced myocardial damage. In this context, we summarize the research advancements pertaining to various Sirtuins involved in autophagy and the molecular mechanisms regulating autophagy. We also elucidate the biological function of Sirtuins across diverse cardiovascular diseases and further discuss the development of novel drugs that regulate Sirtuin-mediated autophagy.
KeywordSirtuins autophagy FOXOs AMPK mTOR cardiovascular diseases Sirtuins-based therapies
PublisherMDPI
DOI10.3390/jcdd10090382
Indexed BySCIE
Language英语
WOS Research AreaCardiovascular System & Cardiology
WOS SubjectCardiac & Cardiovascular Systems
WOS IDWOS:001074102900001
Original Document TypeReview
PMID 37754811
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569316
Collection兰州大学
Corresponding AuthorZhang, Xiaowei
Affiliation
1.Lanzhou Univ, Clin Med Coll 2, Lanzhou 730106, Peoples R China;
2.Lanzhou Univ Second Hosp, Dept Cardiac Surg, Lanzhou 730031, Gansu, Peoples R China;
3.Lanzhou Univ Second Hosp, Dept Cardiol, Lanzhou, Gansu, Peoples R China;
4.Qinghai Univ, Qinghai Prov Peoples Hosp, Xining 810007, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yuqin,Li, Yongnan,Ding, Hong,et al. The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases[J]. Journal of Cardiovascular Development and Disease,2023,10(9).
APA Wang, Yuqin,Li, Yongnan,Ding, Hong,Li, Dan,Shen, Wanxi,&Zhang, Xiaowei.(2023).The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases.Journal of Cardiovascular Development and Disease,10(9).
MLA Wang, Yuqin,et al."The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases".Journal of Cardiovascular Development and Disease 10.9(2023).
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