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BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations
Ma, Tao1,2; Chen, Yan1; Yi, Zhi-Gang2; Li, Yan-Hong2; Bai, Jun2; Li, Li-Juan2,3; Zhang, Lian-Sheng2,3
2023-11
Source PublicationGenes & Diseases   Impact Factor & Quartile
ISSN2352-4820 ; 2352-3042
Volume10Issue:6Pages:2306-2319
page numbers14
AbstractThe bromodomain and extra-terminal (BET) proteins act as readers for lysine acetylation and facilitate the recruitment of transcriptional elongation complexes. BET pro-tein is associated with transcriptional elongation of genes such as c-MYC and BCL-2, and is involved in the regulation of cell cycle and apoptosis. Meanwhile, BET inhibitors (BETi) have regulatory effects on immune checkpoints, immune cells, and cytokine expression. The role of BET proteins and BETi in a variety of tumors has been studied. This paper reviews the recent research progress of BET and BETi in hematologic tumors (mainly leukemia, lymphoma and multiple myeloma) from cellular level studies, animal studies, clinical trials, drug combina-tion, etc. BETi has a promising future in hematologic tumors, and future research directions may focus on the combination with other drugs to improve the efficacy.& COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
KeywordBET BRD4 Clinical trials Hematologic tumors Immunity MYC
PublisherKEAI PUBLISHING LTD
DOI10.1016/j.gendis.2022.03.004
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Genetics & Heredity
WOS SubjectBiochemistry & Molecular Biology ; Genetics & Heredity
WOS IDWOS:001053089500001
Original Document TypeReview
PMID 37554207
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569371
Collection兰州大学
Corresponding AuthorLi, Li-Juan; Zhang, Lian-Sheng
Affiliation
1.Southwest Med Univ, Affiliated Hosp, Dept Hematol, Luzhou 646000, Sichuan, Peoples R China;
2.Lanzhou Univ, Hosp 2, Dept Orthoped, Lanzhou 730000, Gansu, Peoples R China;
3.Lanzhou Univ, Hosp 2, Dept Hematol, 82 Cuiying Rd, Lanzhou 730030, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Ma, Tao,Chen, Yan,Yi, Zhi-Gang,et al. BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations[J]. Genes & Diseases,2023,10(6):2306-2319.
APA Ma, Tao.,Chen, Yan.,Yi, Zhi-Gang.,Li, Yan-Hong.,Bai, Jun.,...&Zhang, Lian-Sheng.(2023).BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations.Genes & Diseases,10(6),2306-2319.
MLA Ma, Tao,et al."BET in hematologic tumors: Immunity, pathogenesis, clinical trials and drug combinations".Genes & Diseases 10.6(2023):2306-2319.
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