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Titanium-Based Superlattice with Fe(III)-Regulable Bandgap and Performance for Optimal and Synergistic Sonodynamic-Chemotherapy Guided by Magnetic Resonance Imaging
Liu, Yanjun1; Qin, Liying2; Tan, Guoying1; Guo, Yanan1; Fan, Yifan1; Song, Nan1; Zhou, Ping2; Yan, Chun-Hua1; Tang, Yu1,3
2023-10-25
Online publication date2023-10
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Impact Factor & Quartile
ISSN1433-7851 ; 1521-3773
EISSN1521-3773
page numbers11
AbstractSuperlattices have considerable potential as sonosensitizers for cancer therapy because of their flexible and tunable band gaps, although they have not yet been reported. In this study, a Ti-based organic-inorganic superlattice with good electron-hole separation was synthesized, which consisted of orderly layered superlattices of 2,2 '-bipyridine-5,5 '-dicarboxylic acid (BPDC) and Ti-O layers. In addition, the superlattice was coordinated with Fe(III) and encapsulated doxorubicin (DOX) to prepare Ti-BPDC@Fe@DOX@PEG (TFDP) after biocompatibility modification. TFDP can realize the simultaneous generation of reactive oxygen species and release of DOX under ultrasound irradiation. Moreover, adjusting the Fe(III) content can effectively modulate the band gap of the superlattice and increase the efficiency of sonodynamic therapy (SDT). The mechanisms underlying this modulation were explored. TFDP with Fe(III) can also be used as a contrast agent for magnetic resonance imaging (MRI). Both in vitro and in vivo experiments demonstrated the ability of TFDP to precisely treat cancer using MRI-guided SDT/chemotherapy. This study expands the applications of superlattices as sonosensitizers with flexible and tailored modifications and indicates that superlattices are promising for precise and customized treatments. In this study, we developed a sonosensitizer by using superlattices for sonodynamic therapy (SDT) with sonication-triggered drug release. Introducing Fe(III) through coordinated interactions and changing the Fe(III) content can efficiently enhance and modulate the band gap and improve the outcomes of SDT. Benefiting from the use of Fe(III) as a contrast agent, magnetic resonance imaging-guided and synergistic therapy can be realized.+image
KeywordIntegrated Therapeutics Precise Treatment Regulated Performance Sonodynamic Therapy Superlattices
PublisherWILEY-V C H VERLAG GMBH
DOI10.1002/anie.202313165
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:001088134600001
Original Document TypeArticle ; Early Access
PMID 37828621
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569502
Collection兰州大学
Corresponding AuthorSong, Nan; Zhou, Ping; Tang, Yu
Affiliation
1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat G, Lanzhou 730000, Peoples R China;
2.Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China;
3.Baotou Res Inst Rare Earths, State Key Lab Baiyunobo Rare Earth Resource Res &, Baotou 014030, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanjun,Qin, Liying,Tan, Guoying,et al. Titanium-Based Superlattice with Fe(III)-Regulable Bandgap and Performance for Optimal and Synergistic Sonodynamic-Chemotherapy Guided by Magnetic Resonance Imaging[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2023.
APA Liu, Yanjun.,Qin, Liying.,Tan, Guoying.,Guo, Yanan.,Fan, Yifan.,...&Tang, Yu.(2023).Titanium-Based Superlattice with Fe(III)-Regulable Bandgap and Performance for Optimal and Synergistic Sonodynamic-Chemotherapy Guided by Magnetic Resonance Imaging.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA Liu, Yanjun,et al."Titanium-Based Superlattice with Fe(III)-Regulable Bandgap and Performance for Optimal and Synergistic Sonodynamic-Chemotherapy Guided by Magnetic Resonance Imaging".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023).
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