兰州大学机构库
The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease
Wang, Jun1,2,3; Liu, Guangyao1,3; Xu, Kun1,2,3; Ai, Kai4; Huang, Wenjing1,2,3; Zhang, Jing1,2,3,5
2023-11
Online publication date2023-08
Source PublicationHUMAN BRAIN MAPPING   Impact Factor & Quartile
ISSN1065-9471 ; 1097-0193
Volume44Issue:16Pages:5357-5371
page numbers15
AbstractA growing body of evidence from neuroimaging studies suggests that inflammatory bowel disease (IBD) is associated with functional and structural alterations in the central nervous system and that it has a potential link to emotional symptoms, such as anxiety and depression. However, the neurochemical underpinnings of depression symptoms in IBD remain unclear. We hypothesized that changes in cortical gamma-aminobutyric acid (GABA+) and glutamine (Glx) concentrations are related to cortical thickness and resting-state functional connectivity in IBD as compared to healthy controls. To test this, we measured whole-brain cortical thickness and functional connectivity within the medial prefrontal cortex (mPFC), as well as the concentrations of neurotransmitters in the same brain region. We used the edited magnetic resonance spectroscopy (MRS) with the MEGA-PRESS sequence at a 3 T scanner to quantitate the neurotransmitter levels in the mPFC. Subjects with IBD (N = 37) and healthy control subjects (N = 32) were enrolled in the study. Compared with healthy controls, there were significantly decreased GABA+ and Glx concentrations in the mPFC of patients with IBD. The cortical thickness of patients with IBD was thin in two clusters that included the right medial orbitofrontal cortex and the right posterior cingulate cortex. A seed-based functional connectivity analysis indicated that there was higher connectivity of the mPFC with the left precuneus cortex (PC) and the posterior cingulate cortex, and conversely, lower connectivity in the left frontal pole was observed. The functional connectivity between the mPFC and the left PC was negatively correlated with the IBD questionnaire score (r = -0.388, p = 0.018). GABA+ concentrations had a negative correlation with the Hamilton Depression Scale (HAMD) score (r = -0.497, p = 0.002). Glx concentration was negatively correlated with the HAMD score (r = -0.496, p = 0.002) and positively correlated with the Short-Form McGill Pain Questionnaire score (r = 0.330, p = 0.046, uncorrected). There was a significant positive correlation between the ratio of Glx to GABA+ and the HAMD score (r = 0.428, p = 0.008). Mediation analysis revealed that GABA+ significantly mediated the main effect of the relationship between the structural and functional alterations and the severity of depression in patients with IBD. Our study provides initial evidence of neurochemistry that can be used to identify potential mechanisms underlying the modulatory effects of GABA+ on the development of depression in patients with IBD.
KeywordCrohn's disease functional MRI inflammatory bowel disease magnetic resonance spectroscopy metabolite resting state ulcerative colitis
PublisherWILEY
DOI10.1002/hbm.26439
Indexed BySCIE
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:001041103700001
Original Document TypeArticle
PMID 37530546
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569519
Collection兰州大学
Corresponding AuthorZhang, Jing
Affiliation
1.Lanzhou Univ, Hosp 2, Dept Magnet Resonance, Lanzhou, Peoples R China;
2.Lanzhou Univ, Clin Sch 2, Lanzhou, Peoples R China;
3.Lanzhou Univ, Hosp 2, Gansu Prov Clin Res Ctr Funct & Mol Imaging, Lanzhou, Peoples R China;
4.Philips Healthcare, Dept Clin & Tech Support, Xian, Peoples R China;
5.Lanzhou Univ, Hosp 2, Dept Magnet Resonance, 82,Cuiyingmen, Lanzhou 730030, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jun,Liu, Guangyao,Xu, Kun,et al. The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease[J]. HUMAN BRAIN MAPPING,2023,44(16):5357-5371.
APA Wang, Jun,Liu, Guangyao,Xu, Kun,Ai, Kai,Huang, Wenjing,&Zhang, Jing.(2023).The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.HUMAN BRAIN MAPPING,44(16),5357-5371.
MLA Wang, Jun,et al."The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease".HUMAN BRAIN MAPPING 44.16(2023):5357-5371.
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