兰州大学机构库
Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling
Ma, Yunhao1; Zhu, Hongmei1; Jiang, Xinrong1; Zhou, Zhongkun1; Zhou, Yong1; Tian, Yanan2; Zhang, Hao1; Sun, Mengze1; Tu, Lixue1; Lu, Juan1; Niu, Yuqing1; Liu, Huanxiang2; Liu, Yingqian1; Chen, Peng1
2023-10
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Impact Factor & Quartile
ISSN1661-6596 ; 1422-0067
EISSN1422-0067
Volume24Issue:20
page numbers12
AbstractChemotherapy is commonly used clinically to treat colorectal cancer, but it is usually prone to drug resistance, so novel drugs need to be developed continuously to treat colorectal cancer. Neocryptolepine derivatives have attracted a lot of attention because of their good cytotoxic activity; however, cytotoxicity studies on colorectal cancer cells are scarce. In this study, the cytotoxicity of 8-methoxy-2,5-dimethyl-5H-indolo[2,3-b] quinoline (MMNC) in colorectal cells was evaluated. The results showed that MMNC inhibits the proliferation of HCT116 and Caco-2 cells, blocks the cell cycle in the G2/M phase, decreases the cell mitochondrial membrane potential and induces apoptosis. In addition, the results of western blot experiments suggest that MMNC exerts cytotoxicity by inhibiting the expression of PI3K/AKT/mTOR signaling pathway-related proteins. Based on these results, MMNC is a promising lead compound for anticancer activity in the treatment of human colorectal cancer.
Keywordneocryptolepine derivatives colorectal cancer antiproliferative activity apoptosis PI3K/AKT/mTOR
PublisherMDPI
DOI10.3390/ijms242015142
Indexed BySCIE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:001089518700001
Original Document TypeArticle
PMID 37894822
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569552
Collection兰州大学
Corresponding AuthorLiu, Yingqian; Chen, Peng
Affiliation
1.Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China;
2.Macao Polytech Univ, Fac Appl Sci, Taipa, Macao, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yunhao,Zhu, Hongmei,Jiang, Xinrong,et al. Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(20).
APA Ma, Yunhao.,Zhu, Hongmei.,Jiang, Xinrong.,Zhou, Zhongkun.,Zhou, Yong.,...&Chen, Peng.(2023).Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(20).
MLA Ma, Yunhao,et al."Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.20(2023).
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