兰州大学机构库
Decreased lipid levels in adult with congenital heart disease: a systematic review and Meta-analysis
Ma, Fengdie1; Li, Peiqiang1; Zhang, Shasha1; Shi, Wenjing1; Wang, Jing1; Ma, Qinglong1; Zhao, Meie2; Nie, Ziyan1; Xiao, Handan1; Chen, Xinyi1; Xie, Xiaodong1
2023-10-27
Source PublicationBMC Cardiovascular Disorders   Impact Factor & Quartile
ISSN1471-2261
Volume23Issue:1
page numbers15
AbstractBackgroundMetabolic disorders were a health problem for many adults with congenital heart disease, however, the differences in metabolic syndrome-related metabolite levels in adults with congenital heart disease compared to the healthy population were unknown.MethodsWe collected 18 studies reporting metabolic syndrome-associated metabolite levels in patients with congenital heart disease. Data from different studies were combined under a random-effects model using Cohen's d values.ResultsThe results found that the levels of total cholesterol (Cohen's d -0.68, 95% CI: -0.91 to -0.45), high-density lipoprotein cholesterol (Cohen's d -0.63, 95% CI: -0.89 to -0.37), and low-density lipoprotein cholesterol (Cohen's d -0.32, 95% CI: -0.54 to -0.10) were significantly lower in congenital heart disease patients compared with controls. Congenital heart disease patients also had a lower body mass index (Cohen's d -0.27, 95% CI: -0.42 to -0.12) compared with controls. On the contrary, congenital heart disease patients had higher levels of hemoglobin A1c (Cohen's d 0.93, 95% CI: 0.17 to 1.70) than controls. Meanwhile, there were no significant differences in triglyceride (Cohen's d 0.07, 95% CI: -0.09 to 0.23), blood glucose (Cohen's d -0.12, 95% CI: -0.94 to 0.70) levels, systolic (Cohen's d 0.07, 95% CI: -0.30 to 0.45) and diastolic blood pressure (Cohen's d -0.10, 95% CI: -0.39 to 0.19) between congenital heart disease patients and controls.ConclusionsThe lipid levels in patients with congenital heart disease were significantly lower than those in the control group. These data will help in the health management of patients with congenital heart disease and guide clinicians.PROSPERO registration numberCRD42022228156.
KeywordAdult congenital heart disease Dyslipidemia TC HDL-C LDL-C
PublisherBMC
DOI10.1186/s12872-023-03455-w
Indexed BySCIE
Language英语
WOS Research AreaCardiovascular System & Cardiology
WOS SubjectCardiac & Cardiovascular Systems
WOS IDWOS:001095945800005
Original Document TypeReview
PMID 37891491
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569783
Collection兰州大学
Corresponding AuthorLi, Peiqiang; Xie, Xiaodong
Affiliation
1.Lanzhou Univ, Inst Genet, Sch Basic Med Sci, Lanzhou, Gansu, Peoples R China;
2.First Peoples Hosp Lanzhou City, Lanzhou, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Ma, Fengdie,Li, Peiqiang,Zhang, Shasha,et al. Decreased lipid levels in adult with congenital heart disease: a systematic review and Meta-analysis[J]. BMC Cardiovascular Disorders,2023,23(1).
APA Ma, Fengdie.,Li, Peiqiang.,Zhang, Shasha.,Shi, Wenjing.,Wang, Jing.,...&Xie, Xiaodong.(2023).Decreased lipid levels in adult with congenital heart disease: a systematic review and Meta-analysis.BMC Cardiovascular Disorders,23(1).
MLA Ma, Fengdie,et al."Decreased lipid levels in adult with congenital heart disease: a systematic review and Meta-analysis".BMC Cardiovascular Disorders 23.1(2023).
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