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Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization
Du, Hao-Xuan1; Wang, Hu1; Ma, Xiao-Peng1; Chen, Hao1; Dai, Ai-Bin1; Zhu, Ke-Xiang1,2,3,4
2023-11
Source PublicationOncology Letters   Impact Factor & Quartile
ISSN1792-1074 ; 1792-1082
EISSN1792-1082
Volume26Issue:5
page numbers21
AbstractMost patients with pancreatic cancer are already in the late stages of the disease when they are diagnosed, and pancreatic cancer is a deadly disease with a poor prognosis. With the advancement of research, immunotherapy has become a new focus in the treatment of tumors. To the best of our knowledge, there is currently no reliable diagnostic or prognostic marker for pancreatic cancer; therefore, the present study investigated the potential of eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) as a predictive and diagnostic marker for pancreatic cancer. Immunohistochemical staining of clinical samples independently verified that EIF2AK2 expression was significantly higher in clinically operated pancreatic cancer tissues than in adjacent pancreatic tissues., and EIF2AK2 expression and differentially expressed genes (DEGs) were identified using downloadable RNA sequencing data from The Cancer Genome Atlas and Genomic Tumor Expression Atlas. In addition, Gene Ontology/Kyoto Encyclopedia of Genes and Genomes analyses and immune cell infiltration were used for functional enrichment analysis of EIF2AK2-associated DEGs. The clinical importance of EIF2AK2 was also determined using Kaplan-Meier survival, Cox regression and time-dependent survival receiver operating characteristic curve analyses, and a predictive nomogram model was generated. Finally, the functional role of EIF2AK2 was assessed in PANC-1 cells using a short hairpin RNA-EIF2AK2 knockdown approach, including CCK-8, wound healing assay, cell cycle and apoptosis assays. The findings suggested that EIF2AK2 may have potential as a diagnostic and prognostic biomarker for patients with pancreatic cancer. Furthermore, EIF2AK2 may provide a new therapeutic target for patients with pancreatic cancer.
Keywordeukaryotic translation initiation factor 2 alpha kinase 2 pancreatic cancer prognosis immune infiltrates tumor microenvironment
PublisherSPANDIDOS PUBL LTD
DOI10.3892/ol.2023.14066
Indexed BySCIE
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:001083990200001
Original Document TypeArticle
PMID 37818134
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569795
Collection兰州大学
Corresponding AuthorZhu, Ke-Xiang
Affiliation
1.Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;
2.Dept Gen Surg, Lanzhou, Gansu, Peoples R China;
3.Lanzhou Univ, Hosp 1, Key Lab Biotherapy & Regenerat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China;
4.Lanzhou Univ, Hosp 1, Dept Gen Surg, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Du, Hao-Xuan,Wang, Hu,Ma, Xiao-Peng,et al. Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization[J]. Oncology Letters,2023,26(5).
APA Du, Hao-Xuan,Wang, Hu,Ma, Xiao-Peng,Chen, Hao,Dai, Ai-Bin,&Zhu, Ke-Xiang.(2023).Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization.Oncology Letters,26(5).
MLA Du, Hao-Xuan,et al."Eukaryotic translation initiation factor 2α kinase 2 in pancreatic cancer: An approach towards managing clinical prognosis and molecular immunological characterization".Oncology Letters 26.5(2023).
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