兰州大学机构库
Microbiota in cancer: molecular mechanisms and therapeutic interventions
Chen, Zhou1,2; Guan, Defeng1,2; Wang, Zhengfeng1,2; Li, Xin3,4; Dong, Shi4; Huang, Junjun2; Zhou, Wence1,4,5
2023-12
Source PublicationMEDCOMM   Impact Factor & Quartile
ISSN2688-2663
EISSN2688-2663
Volume4Issue:6
page numbers44
AbstractThe diverse bacterial populations within the symbiotic microbiota play a pivotal role in both health and disease. Microbiota modulates critical aspects of tumor biology including cell proliferation, invasion, and metastasis. This regulation occurs through mechanisms like enhancing genomic damage, hindering gene repair, activating aberrant cell signaling pathways, influencing tumor cell metabolism, promoting revascularization, and remodeling the tumor immune microenvironment. These microbiota-mediated effects significantly impact overall survival and the recurrence of tumors after surgery by affecting the efficacy of chemoradiotherapy. Moreover, leveraging the microbiota for the development of biovectors, probiotics, prebiotics, and synbiotics, in addition to utilizing antibiotics, dietary adjustments, defensins, oncolytic virotherapy, and fecal microbiota transplantation, offers promising alternatives for cancer treatment. Nonetheless, due to the extensive and diverse nature of the microbiota, along with tumor heterogeneity, the molecular mechanisms underlying the role of microbiota in cancer remain a subject of intense debate. In this context, we refocus on various cancers, delving into the molecular signaling pathways associated with the microbiota and its derivatives, the reshaping of the tumor microenvironmental matrix, and the impact on tolerance to tumor treatments such as chemotherapy and radiotherapy. This exploration aims to shed light on novel perspectives and potential applications in the field. This article presented the role of microbiota in pan-cancer from multiple aspects, including from molecular mechanisms to therapeutic interventions, in order to provide some suggestions for future research on tumor mechanism and clinical treatment.image
Keywordmicrobiota molecular mechanisms oncolytic virotherapy targeted therapy tumor microenvironment
PublisherWILEY
DOI10.1002/mco2.417
Indexed ByESCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:001094743600001
Original Document TypeReview
PMID 37937304
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569894
Collection兰州大学
Corresponding AuthorZhou, Wence
Affiliation
1.Lanzhou Univ, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;
2.Lanzhou Univ, Dept Gastroenterol, Hosp 1, Lanzhou, Gansu, Peoples R China;
3.Lanzhou Univ, Clin Med Coll 2, Lanzhou, Gansu, Peoples R China;
4.Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou, Gansu, Peoples R China;
5.Lanzhou Univ, Hosp 2, Clin Med Coll 1, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhou,Guan, Defeng,Wang, Zhengfeng,et al. Microbiota in cancer: molecular mechanisms and therapeutic interventions[J]. MEDCOMM,2023,4(6).
APA Chen, Zhou.,Guan, Defeng.,Wang, Zhengfeng.,Li, Xin.,Dong, Shi.,...&Zhou, Wence.(2023).Microbiota in cancer: molecular mechanisms and therapeutic interventions.MEDCOMM,4(6).
MLA Chen, Zhou,et al."Microbiota in cancer: molecular mechanisms and therapeutic interventions".MEDCOMM 4.6(2023).
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