兰州大学机构库
ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition
Dai, Huanyu1,2; Wu, Ruiyue2; Zhang, Jiatong2; Dou, Rong2; Xu, Maohong3; Wang, Jiahui4; Wang, Jun3; Su, Fei1,2; Zhang, Tao1,2
2023-08
Online publication date2023-07
Source PublicationCancer Medicine   Impact Factor & Quartile
ISSN2045-7634
Volume12Issue:16Pages:17212-17222
page numbers11
AbstractPurpose: The role and mechanism of zinc finger DHHC protein 11B (ZDHHC11B) in lung adenocarcinoma (LUAD) remain unclear. We, thus, analyzed the expression pattern, biological function, and potential mechanism of ZDHHC11B in LUAD.Methods: The expression level and prognostic value of ZDHHC11B were evaluated based on The Cancer Genome Atlas (TCGA) database and further confirmed in LUAD tissues and cells. The effect of ZDHHC11B on the malignant biological progression of LUAD was evaluated in vitro and in vivo. Gene set enrichment analysis (GSEA) and western blot were used to explore the molecular mechanisms of ZDHHC11B.Results: In vitro, ZDHHC11B inhibited the proliferation, migration, and invasion of LUAD cells and induced the apoptosis of LUAD cells. In addition, ZDHHC11B inhibited the growth of tumors in nude mice. GSEA revealed that ZDHHC11B expression is positively correlated with epithelial-mesenchymal transition (EMT). Western blot analysis demonstrated that molecular markers of EMT were inhibited under ZDHHC11B overexpression conditions.Conclusions: Our findings indicated that ZDHHC11B plays a significant role in inhibiting tumorigenesis via EMT. In addition, ZDHHC11B may be a candidate molecular target for LUAD treatment.
Keywordbiomarkers epithelial-mesenchymal transition lung adenocarcinoma tumorigenesis ZDHHC11B
PublisherWILEY
DOI10.1002/cam4.6345
Indexed BySCIE
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:001027673200001
Original Document TypeArticle
PMID 37434393
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569901
Collection兰州大学
Corresponding AuthorSu, Fei; Zhang, Tao
Affiliation
1.Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China;
2.Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;
3.Lanzhou Univ, Clin Med Coll 2, Lanzhou, Peoples R China;
4.Lanzhou Univ, Coll Pharm, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Dai, Huanyu,Wu, Ruiyue,Zhang, Jiatong,et al. ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition[J]. Cancer Medicine,2023,12(16):17212-17222.
APA Dai, Huanyu.,Wu, Ruiyue.,Zhang, Jiatong.,Dou, Rong.,Xu, Maohong.,...&Zhang, Tao.(2023).ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition.Cancer Medicine,12(16),17212-17222.
MLA Dai, Huanyu,et al."ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition".Cancer Medicine 12.16(2023):17212-17222.
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