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Construction and validation of an NAD plus metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia
Zhu, Yu1; Jian, Jinli1; Niu, Yujie1; Yang, Xiaoxiao1; Guo, Yuancheng1; Zhao, Long1,2; Liu, Bei1,2
2023-12-31
Source PublicationHematology   Impact Factor & Quartile
ISSN1024-5332 ; 1607-8454
Volume28Issue:1
page numbers15
AbstractBackground This study aimed to investigate the potential of a NAD(+) metabolism-related lncRNA signature as a reliable prognostic biomarker for acute myeloid leukemia (AML). Methods Transcriptome profiles and clinical data of AML patients were obtained from The Cancer Genome Atlas (TCGA) database. NAD+ metabolism-related genes (NMRGs) were identified from the KEGG and Reactome databases. Coexpression analysis was used to screen NAD(+) metabolism-related lncRNAs. The NAD(+) metabolismrelated lncRNA signature was constructed using univariate analysis, LASSO regression, and multivariate analysis. High- and low-risk groups were compared for survival, tumor mutation burden, immune cell infiltration, and response to immunotherapy. Enrichment analysis explored the biological functions. Results LINC01679, AC079922.2, TRAF3IP2-AS1, and LINC02465 were identified to construct the risk model. The model exhibited good predictive power and outperformed age and gender as an independent prognostic marker. High-risk patients showed poorer survival, distinct TP53 mutations, and altered immune cell infiltration compared to low-risk patients. Additionally, low-risk patients exhibited greater sensitivity to immunotherapy. Enriched biological functions included leukocyte migration and positive regulation of cytokine production. Conclusions The NAD(+) metabolism-related lncRNA signature shows promise in predicting clinical outcomes for AML patients.
KeywordAcute myeloid leukemia(1) NAD(+) metabolism(2) prognostic signature(3) immune landscape(4) lncRNA(5) >
PublisherTAYLOR & FRANCIS LTD
DOI10.1080/16078454.2023.2231760
Indexed BySCIE
Language英语
WOS Research AreaHematology
WOS SubjectHematology
WOS IDWOS:001023852000001
Original Document TypeArticle
PMID 37417449
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/569903
Collection兰州大学
Corresponding AuthorLiu, Bei
Affiliation
1.Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;
2.Lanzhou Univ, Affiliated Hosp 1, Dept Hematol, Lanzhou, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Yu,Jian, Jinli,Niu, Yujie,et al. Construction and validation of an NAD plus metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia[J]. Hematology,2023,28(1).
APA Zhu, Yu.,Jian, Jinli.,Niu, Yujie.,Yang, Xiaoxiao.,Guo, Yuancheng.,...&Liu, Bei.(2023).Construction and validation of an NAD plus metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia.Hematology,28(1).
MLA Zhu, Yu,et al."Construction and validation of an NAD plus metabolism-related lncRNA signature for predicting the prognosis and immune landscape of acute myeloid leukemia".Hematology 28.1(2023).
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