兰州大学机构库
Maternal Pre-conception Body Mass Index and Fasting Plasma Glucose With the Risk of Pre-term Birth: A Cohort Study Including 4.9 Million Chinese Women
2021-06-15
Source PublicationFRONTIERS IN REPRODUCTIVE HEALTH   Impact Factor & Quartile Of Published Year  The Latest Impact Factor & Quartile
EISSN2673-3153
Volume3
page numbers12
AbstractBackground: To evaluate the associations of pre-conception body mass index (BMI), fasting plasma glucose (FPG) alone and their combination with pre-term birth (PTB) risk.Methods: We conducted a population-based retrospective cohort study with 4,987,129 reproductive-aged women, who participated in National Free Pre-Pregnancy Checkups Project in 2013-2016 and had a singleton delivery before December 2017 in China. All data analyses were conducted in 2018-2021.Results: A total of 339,662 (6.81%) women had pre-term deliveries. Compared with women with normal weight and normal glucose, underweight and normal weight were associated with PTB among hypoglycemia women, the adjusted odd ratios (aORs) were 1.24 (95% CI: 1.05-1.48) and 1.16 (95% CI: 1.07-1.25), respectively; underweight, overweight and obesity were associated with PTB among women with normal glucose, the aORs were 1.09 (95% CI: 1.08-1.10), 1.06 (95% CI: 1.05-1.07) and 1.08 (95% CI: 1.05-1.12), respectively; all the BMI groups were significantly associated with PTB among women with pre-diabetes or diabetes (P < 0.05). The dose-response relationships of BMI with PTB varied in different FPG level, with U-shaped curve in normal glucose and pre-diabetes women, J-shaped in diabetes women, L-shaped in hypoglycemia women. For FPG with PTB, the dose-response relationships were U-shaped in normal weight, overweight, and obesity women, and L-shaped in underweight women.Conclusion: We found that the associations of PTB with BMI varied with levels of FPG, and associations of PTB with FPG varied with levels of BMI. There was a synergistic effect on PTB risk due to abnormal weight and glycemia besides a conventional main effect derived from either of them. Achieving desirable weight and glucose control before conception should be advised.
Keywordbody mass index cohort study fasting plasma glucose pre-conception pre-term birth
PublisherFRONTIERS MEDIA SA
DOI10.3389/frph.2021.622346
Indexed ByESCI
Language英语
WOS Research AreaPublic, Environmental & Occupational Health ; Reproductive Biology
WOS SubjectPublic, Environmental & Occupational Health ; Reproductive Biology
WOS IDWOS:001011500100001
Original Document TypeArticle
PMID 36304061
Citation statistics
Document Type期刊论文
Identifierhttps://ir.lzu.edu.cn/handle/262010/570588
Collection兰州大学
公共卫生学院
Corresponding AuthorYang, Ying; Ma, Xu; Li, Xiaotian
Affiliation
1.Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China;
2.Peking Union Med Coll, Grad Sch, Beijing, Peoples R China;
3.Fudan Univ, Obstet & Gynecol Hosp, Shanghai, Peoples R China;
4.Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai, Peoples R China;
5.Natl Human Genet Resources Ctr, China DOHaD Res Ctr, Beijing, Peoples R China;
6.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing, Peoples R China;
7.Lanzhou Univ, Inst Epidemiol & Stat, Sch Publ Hlth, Lanzhou, Peoples R China;
8.Natl Hlth Commiss Peoples Republ China, Dept Maternal & Child Hlth, Beijing, Peoples R China;
9.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qin,Zhou, Qiongjie,Yang, Ying,et al. Maternal Pre-conception Body Mass Index and Fasting Plasma Glucose With the Risk of Pre-term Birth: A Cohort Study Including 4.9 Million Chinese Women[J]. FRONTIERS IN REPRODUCTIVE HEALTH,2021,3.
APA Xu, Qin.,Zhou, Qiongjie.,Yang, Ying.,Liu, Fangchao.,Wang, Long.,...&Li, Xiaotian.(2021).Maternal Pre-conception Body Mass Index and Fasting Plasma Glucose With the Risk of Pre-term Birth: A Cohort Study Including 4.9 Million Chinese Women.FRONTIERS IN REPRODUCTIVE HEALTH,3.
MLA Xu, Qin,et al."Maternal Pre-conception Body Mass Index and Fasting Plasma Glucose With the Risk of Pre-term Birth: A Cohort Study Including 4.9 Million Chinese Women".FRONTIERS IN REPRODUCTIVE HEALTH 3(2021).
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