| Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank | |
| Chen, Xiaowan1,2,3,4; Hu, Kejia2; Song, Huan5,6,7; Yin, Li8; Kaijser, Magnus2,9; Gurholt, Tiril P.10,11; Andreassen, Ole A.10,11; Valdimarsdottir, Unnur2,7,12; Fang, Fang2; Duan, Maoli3,4 | |
| 2024-02-01 | |
| Source Publication | BJPsych Open Impact Factor & Quartile Of Published Year The Latest Impact Factor & Quartile |
| ISSN | 2056-4724 |
| Volume | 10Issue:2 |
| page numbers | 8 |
| Abstract | Background Hearing loss and tinnitus have been proposed as potential indicators of impaired mental health and brain morphological changes.Aims To assess the associations of hearing loss and tinnitus with the risk of depression and anxiety and with brain volume.Method We conducted a community-based cohort study including 129 610 participants aged 40-69 years at recruitment to the UK Biobank with a follow-up period during 2006-2021 to estimate the risk of depression and anxiety after detection of hearing loss and reported tinnitus. We also assessed the associations of hearing loss and tinnitus with brain volume in a subsample with available brain magnetic resonance imaging data (N = 5222).Results We observed an increased risk of depression among individuals with hearing loss (hazard ratio [HR] 1.14, 95% CI 1.03-1.26), tinnitus (HR 1.30, 95% CI 1.21-1.41) or both (HR 1.32, 95% CI 1.15-1.52), compared with individuals with neither hearing loss nor tinnitus. Similar results were noted for anxiety (HR 1.18, 95% CI 1.07-1.30 for hearing loss; HR 1.32, 95% CI 1.22-1.43 for tinnitus; and HR 1.48, 95% CI 1.30-1.68 for both). Hearing loss was associated with decreased overall brain volume as well as decreased volume of different brain regions. The latter associations disappeared after adjustment for whole intracranial volume. Tinnitus was associated with greater left accumbens and right occipital pole volume after adjustment for the whole intracranial volume.Conclusions Individuals with tinnitus are at increased risk of depression and anxiety. Hearing loss, on the other hand, is associated with both mood disorders and altered brain morphology. |
| Keyword | Hearing loss tinnitus mood disorders brain volume |
| Publisher | CAMBRIDGE UNIV PRESS |
| DOI | 10.1192/bjo.2023.634 |
| Indexed By | SCIE ; SSCI |
| Language | 英语 |
| WOS Research Area | Psychiatry |
| WOS Subject | Psychiatry |
| WOS ID | WOS:001156867400001 |
| Original Document Type | Article |
| PMID | 38297917 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/583162 |
| Collection | 第一临床医学院 |
| Affiliation | 1.Lanzhou Univ, Dept Otolaryngol Head & Neck Surg, Hosp 1, Lanzhou, Gansu, Peoples R China; 2.Karolinska Inst, Inst Environm Med, Unit Integrat Epidemiol, Stockholm, Sweden; 3.Karolinska Univ Hosp, Dept Otolaryngol Head & Neck Surg & Audiol & Neuro, Stockholm, Sweden; 4.Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden; 5.Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu, Peoples R China; 6.Sichuan Univ, Med X Ctr Informat, Chengdu, Peoples R China; 7.Univ Iceland, Fac Med, Ctr Publ Hlth Sci, Reykjavik, Iceland; 8.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden; 9.Karolinska Univ Hosp, Dept Neuroradiol, Stockholm, Sweden; 10.Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway; 11.Univ Oslo, Inst Clin Med, Oslo, Norway; 12.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Ctr Publ Hlth Sci, Boston, MA USA |
| First Author Affilication | First Clinical School |
| First Signature Affilication | First Clinical School |
| Recommended Citation GB/T 7714 | Chen, Xiaowan,Hu, Kejia,Song, Huan,et al. Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank[J]. BJPsych Open,2024,10(2). |
| APA | Chen, Xiaowan.,Hu, Kejia.,Song, Huan.,Yin, Li.,Kaijser, Magnus.,...&Duan, Maoli.(2024).Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank.BJPsych Open,10(2). |
| MLA | Chen, Xiaowan,et al."Depression, anxiety and brain volume after hearing loss and tinnitus: cohort study in the UK Biobank".BJPsych Open 10.2(2024). |
| Files in This Item: | |||||
| File Name/Size | DocType | Version | Access | License | |
| Chen-2024-Depression（462KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | Application Full Text |
