| Hypoxia inducible factor-1a related mechanism and TCM intervention in process of early fracture healing | |
Zhang, Wenxian1; Yang, Fusen2; Yan, Qikai1,3; Li, Jiahui2; Zhang, Xiaogang1; Jiang, Yiwei1; Dai, JY(戴建业)2 | |
| 2024-01 | |
| Online publication date | 2024-02 |
| Source Publication | Chinese Herbal Medicines Impact Factor & Quartile Of Published Year The Latest Impact Factor & Quartile |
| ISSN | 1674-6384 |
| Volume | 16Issue:1Pages:56-69 |
| page numbers | 14 |
| Abstract | As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients' physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor -1a (HIF-1a), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1a and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of TCM in treating fractures based on the HIF molecular mechanism. (c) 2023 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keyword | fracture healing hypoxia hypoxia inducible factor -1 a traditional chinese medicine molecular mechanism |
| Publisher | ELSEVIER SINGAPORE PTE LTD |
| DOI | 10.1016/j.chmed.2023.09.006 |
| Indexed By | ESCI |
| Language | 英语 |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:001168237100001 |
| Original Document Type | Review |
| PMID | 38375046 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/585097 |
| Collection | 药学院 |
| Affiliation | 1.Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou 730000, Peoples R China; 2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China; 3.Xian Hosp Tradit Chinese Med, Xian 710021, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Wenxian,Yang, Fusen,Yan, Qikai,et al. Hypoxia inducible factor-1a related mechanism and TCM intervention in process of early fracture healing[J]. Chinese Herbal Medicines,2024,16(1):56-69. |
| APA | Zhang, Wenxian.,Yang, Fusen.,Yan, Qikai.,Li, Jiahui.,Zhang, Xiaogang.,...&Dai, Jianye.(2024).Hypoxia inducible factor-1a related mechanism and TCM intervention in process of early fracture healing.Chinese Herbal Medicines,16(1),56-69. |
| MLA | Zhang, Wenxian,et al."Hypoxia inducible factor-1a related mechanism and TCM intervention in process of early fracture healing".Chinese Herbal Medicines 16.1(2024):56-69. |
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