| Tumor-specific Peptide Probes and the Applications in Bioimaging | |
Wang, Bo1,2; Cai, Xiangdong1,2; Xiao, JX(肖建喜)1,2 | |
| 2024-03-15 | |
| Source Publication | ACTA CHIMICA SINICA Impact Factor & Quartile Of Published Year The Latest Impact Factor & Quartile |
| ISSN | 0567-7351 |
| Volume | 82Issue:3Pages:367-376 |
| page numbers | 10 |
| Abstract | The tumor is a complex system composed of various elements, encompassing cells, extracellular matrix, and the tumor microenvironment. Each of these distinct factors plays a pivotal role in the development and progression of tumors. The specific analysis of tumor-associated cells, extracellular matrix, and tumor microenvironment is of paramount importance for precise diagnosis and targeted therapy of tumors. Peptide probes have gained substantial prominence in investigations focused on tumor-specific imaging, primarily attributed to their notable attributes, including high specificity, biocompatibility, tissue-penetrating capabilities, and straightforward preparation processes. This review comprehensively summarizes the peptide probes for specific imaging of tumor-associated cells. The specific recognition of cells was by binding various cellular markers, such as the epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), and folate receptor (FR alpha) for tumor cells. Additionally, the biomarkers include CD206, neurokinin-1 receptor (NK-1R), and CD11c for immune cells, along with nucleolin and integrins for tumor vascular endothelial cells. Furthermore, this comprehensive review encapsulates peptide probes designed for the specific targeting of extracellular matrix proteins and their applications in tumor-specific imaging. The focal points among these protein targets encompass pathological collagen, matrix metalloproteinases, and fibronectin. Of particular significance is the potential of pathological collagen as a highly promising extracellular matrix target for achieving tumor-specific imaging. The review comprehensively outlines tumor-specific peptide probes responsive to various factors within the tumor microenvironment. Commonly encountered responsive factors in the tumor microenvironment include mild acidity (pH), heightened enzyme activity, such as matrix metalloproteinases and cathepsin, and elevated levels of oxidative stress. It further explores their versatile applications in bioimaging. Lastly, this review discusses the clinical applications of tumor-specific peptide probes in diagnostic practices. It explores the current challenges and prospects of these peptide probes, elucidating their potential contributions to precision diagnosis and personalized treatment of tumors, including precise surgical navigation and their synergistic use with immunotherapy. |
| Keyword | cancer tumor microenvironment extracellular matrix peptide probes biological imaging |
| Publisher | SCIENCE PRESS |
| DOI | 10.6023/A23100448 |
| Indexed By | SCIE |
| Language | 中文 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:001209286100012 |
| Original Document Type | Review |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.lzu.edu.cn/handle/262010/592209 |
| Collection | 兰州大学 化学化工学院 |
| Affiliation | 1.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China; 2.Gansu Engn Res Ctr Med Collagen, Lanzhou 730000, Peoples R China |
| First Author Affilication | College of Chemistry and Chemical Engineering |
| First Signature Affilication | College of Chemistry and Chemical Engineering |
| Recommended Citation GB/T 7714 | Wang, Bo,Cai, Xiangdong,Xiao, Jianxi. Tumor-specific Peptide Probes and the Applications in Bioimaging[J]. ACTA CHIMICA SINICA,2024,82(3):367-376. |
| APA | Wang, Bo,Cai, Xiangdong,&Xiao, Jianxi.(2024).Tumor-specific Peptide Probes and the Applications in Bioimaging.ACTA CHIMICA SINICA,82(3),367-376. |
| MLA | Wang, Bo,et al."Tumor-specific Peptide Probes and the Applications in Bioimaging".ACTA CHIMICA SINICA 82.3(2024):367-376. |
| Files in This Item: | |||||
| File Name/Size | DocType | Version | Access | License | |
| Wang-2024-Tumor-spec（3213KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
