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新型酸激活肽的设计、合成及抗肿瘤活性研究
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
常琳琳
Favorite
  |  
  
Submit date:2023/11/15
抗癌肽
anticancer peptides
穿膜肽
cell penetrating peptides
酸激活
acid-activated
抗肿瘤活性
antitumor activity
低毒性
low toxicity
高稳定碳点纳米复合材料应用于舌鳞癌标记和治疗的研究
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
秦丽颖
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  |  
  
Submit date:2023/11/15
舌鳞癌
Tongue squamous cell carcinoma
荧光材料
Fluorescent materials
碳点
Carbon dots
生物标记
Biolabeling
聚多巴胺
Polydopamine
光热治疗
Photothermal therapy
计算机辅助BH3模拟肽的设计及活性验证
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
付成功
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  |  
  
Submit date:2023/11/15
自噬
Autophagy
Beclin 1
Beclin 1
Bcl-XL
Bcl-XL
BH3模拟肽
the BH3-mimetic peptides
计算机辅助药物设计
computer-aided drug design
线粒体靶向抗菌肽Polybia-CP类似物的抗肿瘤机制研究
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
马玲
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  |  
  
Submit date:2023/11/15
抗菌肽
Antimicrobial peptides
黑色素瘤
melanoma
抗肿瘤机制
antitumor mechanism
线粒体损伤
mitochondrial damage
免疫原性细胞死亡
immunogenic cell death
异腈与胺合成脲的生物正交反应
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
张奇
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  |  
  
Submit date:2023/11/15
生物正交反应
Bioorthogonal Reactins
脲
Ureas
反应速率常数k
Reaction rate constant k
选择性标记
Selective marking
荧光探针
Fluorescent probe
一种细胞外基质高亲和的新型细胞穿膜肽PLGF-2C的鉴定、应用与机制研究
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
唐媛媛
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  |  
  
Submit date:2023/11/15
细胞穿膜肽
cell-penetrating peptides
基质靶向肽
matrix targeting peptide
ECM屏障
ECM barrier
肿瘤球渗透
penetration in spheroids
重组白喉毒素无毒突变体CRM197可溶表达研究
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
夏润洁
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  |  
  
Submit date:2023/11/15
CRM197
CRM197
大肠杆菌表达系统
E. coli Expression System
可溶性表达
Soluble Expression
纯化工艺
Purification Process
结构确证
Structure Confirmation
免疫原性
Immunogenicity
One New Acid-Activated Hybrid Anticancer Peptide by Coupling with a Desirable pH-Sensitive Anionic Partner Peptide
期刊论文
ACS Omega, 2023
Authors:
Chang, Linlin
;
Wu, Xiaoyan
;
Ran, Kaixin
;
Tian, Yali
;
Ouyang, Xu
;
Liu, Hui
;
Gou, Sanhu
;
Zhang, Yun
;
Ni, Jingman
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  |  
  
Submit date:2023/04/12
Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 239
Authors:
Ma, Ling
;
Huang, Sujie
;
Xie, Huan
;
Ma, Panpan
;
Jia, Bo
;
Yao, Yufan
;
Gao, Yuxuan
;
Li, Wenyuan
;
Song, Jingjing
;
Zhang, Wei
...
Ma, Ling
;
Huang, Sujie
;
Xie, Huan
;
Ma, Panpan
;
Jia, Bo
;
Yao, Yufan
;
Gao, Yuxuan
;
Li, Wenyuan
;
Song, Jingjing
;
Zhang, Wei
Favorite
  |  
  
Submit date:2022/07/25
Antimicrobial peptide
Anticancer
Fatty acid modification
Self-assembly
Membrane disruption
Necroptosis
Influence of chain length on the anticancer activity of the antimicrobial peptide CAMEL with fatty acid modification
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 239
Authors:
Ma, Ling
;
Huang, Sujie
;
Xie, Huan
;
Ma, Panpan
;
Jia, Bo
;
Yao, Yufan
;
Gao, Yuxuan
;
Li, Wenyuan
;
Song, Jingjing
;
Zhang, Wei
...
Ma, Ling
;
Huang, Sujie
;
Xie, Huan
;
Ma, Panpan
;
Jia, Bo
;
Yao, Yufan
;
Gao, Yuxuan
;
Li, Wenyuan
;
Song, Jingjing
;
Zhang, Wei
Favorite
  |  
  
Submit date:2022/11/09
Antimicrobial peptide
Anticancer
Fatty acid modification
Self-assembly
Membrane disruption
Necroptosis