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兰州大学机构库

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Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 139
Authors:  Zhang, Mi;  Zhu, Li-Zu;  Yang, Cheng-Jie;  Yan, Jia-Xuan;  Wang, Zhi-Ping;  Bai, Yin-Peng;  Peng, Li-Zeng;  Luo, Hong-Bo;  Zhang, Zhi-Jun;  Li, Lei...Zhang, Mi;  Zhu, Li-Zu;  Yang, Cheng-Jie;  Yan, Jia-Xuan;  Wang, Zhi-Ping;  Bai, Yin-Peng;  Peng, Li-Zeng;  Luo, Hong-Bo;  Zhang, Zhi-Jun;  Li, Lei;  Xu, Chuan-Rui;  Liu, Ying-Qian
Favorite  |    Submit date：2023/11/28
Anti -tumor activity  Camptothecin  Fluorine  Synthesis  Hepatocellular carcinoma  
Facile synthesis of GSH-triggered skeleton-cleavable hyperbranched polymer prodrug as unimolecular micelles for tumor-specific camptothecin delivery 期刊论文
EUROPEAN POLYMER JOURNAL, 2023, 卷号: 196
Authors:  Li, Jie;  Yang, Yubin;  Liu, P(刘鹏)
Favorite  |    Submit date：2023/09/04
Cell proliferation  Chemotherapy  Controlled drug delivery  Dendrimers  Micelles  Musculoskeletal system  Targeted drug delivery  Tumors  Bottom up  Camptothecins  Drug release  Facile synthesis  GSH-triggered disintegration  Hyperbranched polymer prodrug  Hyperbranched polymers  Prodrugs  Tumor-specific chemotherapy  Unimolecular micelles  
脂肪酸修饰的喜树碱-氨基酸前药的抗炎活性研究 学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:  姚玙璠
Favorite  |    Submit date：2023/11/15
脓毒症  Sepsis  细胞因子风暴  Cytokine storm  拓扑异构酶1  Topoisomerase 1  喜树碱前药  Camptothecin prodrug  氨基酸  Amino acids,  脂肪酸  Fatty acids  
喜树碱衍生物通过阻止HCT116 细胞的周期进程实现抗肿瘤作用 学位论文
医学学士, 兰州: 兰州大学, 2023
Authors:  刘英杰
Favorite  |    Submit date：2023/11/15
喜树碱衍生物  Camptothecin derivatives  MTT实验  MTT experiment  细胞周期  Cell cycle  结直肠癌  Colorectal cancer  
Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 250
Authors:  Liu, Xuefeng;  Cui, Hongmei;  Li, Mi;  Chai, Zuohu;  Wang, Haibo;  Jin, Xiaojie;  Dai, Fang;  Liu, Yongqi;  Zhou, Bo
Favorite  |    Submit date：2023/04/12
Anticancer  Curcumin  Thioredoxin reductase  Reactive oxygen species  Apoptosis  Ferroptosis  
Thiol-Michael addition based conjugate for glutathione activation and release 期刊论文
BIOORGANIC CHEMISTRY, 2022, 卷号: 129
Authors:  Liu, Zhengkun;  Chen, Shasha;  Wang, Hao;  Zhao, Yaofeng;  Dong, Shouliang
Favorite  |    Submit date：2023/01/03
Thiol-Michael addition  Conjugate  Glutathione activation  Drug release  Antitumor  

Design and synthesis of novel 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives as potential high selectivity and low toxicity topoisomerase I inhibitors for hepatocellular carcinoma

 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2022, 卷号: 200
Authors:  Bai, Yin-Peng;  Yang, Cheng-Jie;  Deng, Nan;  Zhang, Mi;  Zhang, Zhi-Jun;  Li, Lei;  Zhou, Yong;  Luo, Xiong-Fei;  Xu, Chuan-Rui;  Zhang, Bao-Qi...Bai, Yin-Peng;  Yang, Cheng-Jie;  Deng, Nan;  Zhang, Mi;  Zhang, Zhi-Jun;  Li, Lei;  Zhou, Yong;  Luo, Xiong-Fei;  Xu, Chuan-Rui;  Zhang, Bao-Qi;  Ma, Yue;  Liu, Ying-Qian
Favorite  |    Submit date：2022/07/01
Camptothecin  Fluorine  Cinnamic acid  Antitumor activity  Synthesis  
Baylis-Hillman Adducts as a Versatile Module for ConstructingFluorogenic Release System br 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 8, 页码: 6056-6069
Authors:  Zhao, Lanning;  Qu, Yuan;  Zhang, Fang;  Di Ma;  Gao, Hao;  Gan, Lu;  Zhang, Hong;  Zhang, Shengxiang;  Fang, Jianguo
Favorite  |    Submit date：2022/07/01
DEVELOPMENT AND EVALUATION OF COLON-SPECIFIC RELEASING NANOEMULSION / HYDROGEL PELLETS OF CAMPTOTHECIN 期刊论文
ACTA POLONIAE PHARMACEUTICA, 2022, 卷号: 79, 期号: 4, 页码: 531-541
Authors:  Xu, Zheng;  Lv, Huijuan;  LI, Yun;  Qiu, Guoyu;  Wang, Yudong;  Zhang, Jianing;  Zhang, Zengkui;  Yang, Zhigang;  Liu, Ying;  Shi, Yanbin...Xu, Zheng;  Lv, Huijuan;  LI, Yun;  Qiu, Guoyu;  Wang, Yudong;  Zhang, Jianing;  Zhang, Zengkui;  Yang, Zhigang;  Liu, Ying;  Shi, Yanbin
Favorite  |    Submit date：2023/01/03
camptothecin  nanoemulsion  hydrogel pellets  colon-specific release  
Integration of a Diselenide Unit Generates Fluorogenic Camptothecin Prodrugs with Improved Cytotoxicity to Cancer Cells 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 24, 页码: 17979-17991
Authors:  Zhao, Jintao;  Wang, Zihua;  Zhong, Miao;  Xu, Qianhe;  Li, Xinming;  Chang, Bingbing;  Fang, Jianguo
Favorite  |    Submit date：2022/07/01