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Anti-inflammatory efficacy and relevant SAR investigations of novel chiral pyrazolo isoquinoline derivatives: Design, synthesis, in-vitro, in-vivo, and computational studies targeting iNOS
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256
Authors:
Akhtar, Maryam
;
Niu, Jiabin
;
Zhu, Yujie
;
Luo, Zhaoyi
;
Tian, Ting
;
Dong, Yuanliang
;
Wang, Yuan
;
Fareed, Muhammad Subaan
;
Lin, Li
Favorite
  |  
  
Submit date:2023/07/18
Anti-inflammatory
Pyrazolo isoquinoline
Nitric oxide inhibition
Inducible nitric oxide synthase
Celecoxib
N-乙酰血清素减轻过氧化氢诱导的PC12细胞损伤的机制研究
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
康继贺
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  |  
  
Submit date:2023/11/15
N-乙酰血清素
N-acetyl serotonin
活性氧
reactive oxygen species
脊髓损伤
spinal cord injury
细胞凋亡
apoptosis: PI3K/AKT pathway
PI3K/AKT通路
大黄蒽醌类物质对炎症性肺与肠通透性损伤的影响及机制研究
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
刘桂元
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  |  
  
Submit date:2023/11/15
大黄蒽醌
Rhubarb anthraquinone
紧密连接蛋白
tight junction proteins
细胞通透性
cell permeability
RhoA/Rock1信号通路
RhoA/Rock1 signaling pathway
神经型一氧化氮合酶通过NF-κB信号通路调控脂多糖诱导的大鼠心肌H9C2细胞脓毒症炎症性损伤
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
马鑫
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  |  
  
Submit date:2023/11/15
脓毒症
Sepsis
神经型一氧化氮合酶
Neuronal nitric oxide synthase
NF-κB
NF-κB
炎症反应
inflammatory response
心肌损伤
myocardial injury
酵母提取物对大鼠酒精性肝损伤的保护作用研究
学位论文
公共卫生硕士, 兰州: 兰州大学, 2023
Authors:
蔺子晗
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  |  
  
Submit date:2023/11/15
酵母提取物
yeast extract
氧化应激
oxidative stress
炎症反应
inflammatory response
酒精
alcohol
肠道菌群
intestinal flora
代谢组学
metabolomics
PD-1/PD-L1 inhibition promotes hepatic regeneration in small-for-size liver following extended hepatectomy
期刊论文
CYTOKINE, 2022, 卷号: 159
Authors:
Yan, Xin
;
Shi, Ji-Hua
;
Xue, Jian-Feng
;
Guo, Wen-Zhi
;
Li, Bin
;
Zhang, Shui-Jun
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  |  
  
Submit date:2022/11/09
Small for size syndrome
Liver regeneration
Macrophage polarization
Programmed cell death protein 1
Programmed cell death protein ligand 1
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2022, 卷号: 85, 期号: 7, 页码: 1779-1788
Authors:
Samuvel, Devadoss J.
;
Nguyen, Nga T.
;
Jaeschke, Hartmut
;
Lemasters, John J.
;
Wang, Xiaojuan
;
Choo, Yeun-Mun
;
Hamann, Mark T.
;
Zhong, Zhi
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  |  
  
Submit date:2022/11/09
Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach
期刊论文
Computational Intelligence and Neuroscience, 2022, 卷号: 2022
Authors:
Lang, Wanying
;
Yang, Feng
;
Cai, Fanfan
;
Shi, Wengui
;
Dong, Min
;
An, Qi
;
Li, Yanping
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  |  
  
Submit date:2023/01/03
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway
期刊论文
CELL CYCLE, 2022, 卷号: 21, 期号: 21, 页码: 2268-2282
Authors:
Kang, Jihe
;
Wang, Yidian
;
Guo, Xudong
;
He, Xuegang
;
Liu, Wenzhao
;
Chen, Haiwei
;
Wang, Zhaoheng
;
Lin, Aixin
;
Kang, Xuewen
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  |  
  
Submit date:2022/07/25
N-acetylserotonin
spinal cord injury
apoptosis
oxidative stress
PI3K
AKT pathway
一类手性异喹啉衍生物抗炎作用研究及 SAR 分析
学位论文
理学硕士, 兰州: 兰州大学, 2022
Authors:
MARYAM AKHTAR
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  |  
  
Submit date:2023/03/13
抗炎
新药发现
异喹啉
前列腺素 E2
一氧化氮