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超声联合多功能纳米复合物在NSCLC分子靶向治疗的应用研究
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
吕文豪
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  |  
  
Submit date:2023/11/15
NSCLC
NSCLC
TAMs
TAMs
光热治疗
photothermal therapy
金基纳米复合物
gold-based nanocomplexes
声动力治疗
Sonodynamic therapy
EGFR-TKI耐药
EGFR-TKI resistance
超声增强成像
Contrast-enhanced ultrasound imaging
酪氨酸激酶抑制剂经 RhoA/ROCK 通路对血压和心脏损害的相关机制及干预研究
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
王文娟
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  |  
  
Submit date:2023/11/15
高血压,心脏损伤,阿帕替尼, RhoA/ROCK信号通路,Y27632
hypertension, cardiac injury, Apatinib, RhoA/ROCK signaling pathway, Y27632
基于阳离子骨架设计核和线粒体靶向的荧光探针
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
谢涛
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  |  
  
Submit date:2023/11/15
荧光探针
Fluorescent probe, Nucleus, Viscosity, Hydrogen peroxide, Mitochondria
细胞核
粘度
过氧化氢
线粒体
设计多功能荧光探针检测活细胞的氧化还原信号及粘度
学位论文
理学硕士, 兰州: 兰州大学, 2023
Authors:
陈浩
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  |  
  
Submit date:2023/11/15
多功能荧光探针,细胞核,线粒体,氧化还原信号,粘度
Mutifunctional fluorescent probes
Nucleus
Mitochondrial
Redox signal
Viscosity
线粒体靶向抗菌肽Polybia-CP类似物的抗肿瘤机制研究
学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:
马玲
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  |  
  
Submit date:2023/11/15
抗菌肽
Antimicrobial peptides
黑色素瘤
melanoma
抗肿瘤机制
antitumor mechanism
线粒体损伤
mitochondrial damage
免疫原性细胞死亡
immunogenic cell death
KKS 参与椎间盘退变:缓激肽通过部分激活 B2R/PI3K/AKT 通路抑制椎间盘退变
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
邱晓明
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  |  
  
Submit date:2023/11/15
缓激肽
Bradykinin
氧化应激
oxidative stress
凋亡
apoptosis
PLGA 微球
PLGA microspheres
椎间盘退变
intervertebral disc degeneration
受体酪氨酸激酶AXL介导实验性自身免疫性脑脊髓炎小胶质细胞极化的机制研究及靶向药物筛选
学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:
孙梦娇
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Submit date:2023/11/15
受体酪氨酸激酶
Receptor Tyrosine Kinase
多发性硬化
AXL
实验性自身免疫性脑脊髓炎
Multiple Sclerosis
小胶质细胞
Experimental Autoimmune Encephalomyelitis
药物筛选
Microglia
Drug Screening
1H-Indazoles derivatives targeting PI3K/AKT/mTOR pathway: Synthesis, anti-tumor effect and molecular mechanism
期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 133
Authors:
Wang, Shuai
;
Shi, Jian-Tao
;
Wang, Xing-Rong
;
Mu, Hong-Xia
;
Wang, Xue-Ting
;
Xu, Kai-Yan
;
Wang, Qing-Shan
;
Chen, Shi-Wu
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  |  
  
Submit date:2023/04/12
PI3K
AKT
mTOR
Indazole
Antitumor
Mitochondria-targeted iridium-based photosensitizers enhancing photodynamic therapy effect by disturbing cellular redox balance
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2023, 卷号: 195, 页码: 121-131
Authors:
Zhong, Miao
;
Zhang, Baoxin
;
He, Jian
;
Liu, Qiang
;
Fang, Jianguo
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  |  
  
Submit date:2023/04/12
Photodynamic therapy
Iridium (III) complex
Redox metabolism
Reactive oxygen species
Thioredoxin reductase
Cellular and Intravital Imaging of NAD(P)H by a Red-Emitting Quinolinium-Based Fluorescent Probe that Features a Shift of Its Product from Mitochondria to the Nucleus
期刊论文
ANALYTICAL CHEMISTRY, 2023, 卷号: 95, 期号: 2, 页码: 1335-1342
Authors:
Duan, De-Chen
;
Liu, Junru
;
Zheng, Ya-Long
;
Chen, Hao
;
Zhang, Xinying
;
Zhang, Yu
;
Dai, Fang
;
Zhang, SX(张胜祥)
;
Zhou, Bo
Favorite
  |  
  
Submit date:2023/04/12
Fluorescence spectroscopy
Fluorophores
Mitochondria
Biological process
Cellulars
Electron carrier
Fluorescent probes
Hydrogen donor
Living cell
Mitochondrias
Pathophysiological
Red-emitting
Small molecules