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兰州大学机构库

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基于Plectin-1的多肽偶联物设计、合成及活性评价 学位论文
医学硕士, 兰州: 兰州大学, 2023
Authors:  王聪
Favorite  |    Submit date：2023/11/15
网格蛋白-1  plectin-1  多肽-药物偶联物  peptide-drug conjugate  多肽-核素偶联物  peptide-radionuclide conjugate  癌症诊疗一体化  cancer theranostics  胰腺癌  pancreatic cancer  
基于天然氨基酸的多肽后期化学修饰策略研究 学位论文
理学博士, 兰州: 兰州大学, 2023
Authors:  刘玉洋
Favorite  |    Submit date：2023/11/15
多肽化学修饰  Peptide Chemical modification  羧酸  Carboxylic acid  色氨酸  Tryptophan  肟醚  Oxime ether  MBH碳酸脂  MBH Carbonates  固相多肽合成  Solid-Phase Peptides Synthesis  
新型酸激活肽的设计、合成及抗肿瘤活性研究 学位论文
医学博士, 兰州: 兰州大学, 2023
Authors:  常琳琳
Favorite  |    Submit date：2023/11/15
抗癌肽  anticancer peptides  穿膜肽  cell penetrating peptides  酸激活  acid-activated  抗肿瘤活性  antitumor activity  低毒性  low toxicity  
3,5-二氯代酪氨酸构建新型酸激活细胞穿膜肽的设计、合成与应用 学位论文
理学博士, 兰州: 兰州大学, 2023
Authors:  薛宏祥
Favorite  |    Submit date：2023/11/15
细胞穿膜肽  Cell penetrating peptides  酸激活细胞穿膜肽  Acid-active cell penetrating peptides  药物递送  Drug delivery  3,5-二氯代酪氨酸  3,5-dichlorotyrosine  电荷转变  shift of charge  
Constructing new acid-activated anticancer peptide by attaching a desirable anionic binding partner peptide 期刊论文
JOURNAL OF DRUG TARGETING, 2022, 卷号: 30, 期号: 9, 页码: 973-982
Authors:  Zhang, Yun;  Chang, Linlin;  Bao, Hexin;  Wu, Xiaoyan;  Liu, Hui;  Gou, Sanhu;  Zhang, Jingying;  Ni, Jingman
Favorite  |    Submit date：2022/07/01
Anticancer peptide  anionic binding partner  acid activated  low toxicity  enzymatic stability  
Novel synovial targeting peptide-sinomenine conjugates as a potential strategy for the treatment of rheumatoid arthritis 期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 卷号: 617
Authors:  Zhang, Tianyue;  Ouyang, Xu;  Gou, Sanhu;  Zhang, Yun;  Yan, Na;  Chang, Linlin;  Li, Beibei;  Zhang, Fangyan;  Liu, Hui;  Ni, Jingman...Zhang, Tianyue;  Ouyang, Xu;  Gou, Sanhu;  Zhang, Yun;  Yan, Na;  Chang, Linlin;  Li, Beibei;  Zhang, Fangyan;  Liu, Hui;  Ni, Jingman
Favorite  |    Submit date：2022/07/01
Peptide-drug conjugates  Sinomenine  Rheumatoid arthritis  Target delivery  
去芳构化-芳构化策略实现含酪氨酸多肽的特异性修饰的研究 学位论文
理学博士, 兰州: 兰州大学, 2021
Authors:  王鹏新
Favorite  |    Submit date：2023/11/15
多肽特异性修饰  site-specific modification of peptide  多肽药物  peptide drug  酪氨酸  tyrosine  去芳构化-芳构化反应  dearomatization-rearomatization reaction  环己二烯酮  cyclohexadienone  
Potent Antimicrobial and Antibiofilm Activities of Feleucin-K3 Analogs Modified by alpha-(4-Pentenyl)-Ala against Multidrug-Resistant Bacteria 期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 5
Authors:  Guo, Xiaomin;  Yan, Tiantian;  Rao, Jing;  Yue, Xin;  Pei, Xiong;  Deng, Jiahui;  Sun, Wangsheng;  Yang, Wenle;  Zhang, Bangzhi;  Xie, JQ(谢俊秋)...Guo, Xiaomin;  Yan, Tiantian;  Rao, Jing;  Yue, Xin;  Pei, Xiong;  Deng, Jiahui;  Sun, Wangsheng;  Yang, Wenle;  Zhang, Bangzhi;  Xie, JQ(谢俊秋)
Adobe PDF(5637Kb)  |  Favorite  |    Submit date：2021/06/17
antimicrobial peptide analogsunnatural hydrophobic amino acidalpha-(4-pentenyl)-Alaantimicrobial activityantibiofilm activity  
Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives 期刊论文
RSC ADVANCES, 2021, 卷号: 11, 期号: 21, 页码: 12915-12928
Authors:  Su, Chunhong;  Ren, XiaoJun;  Nie, Fang;  Li, Tiangang;  Lv, Wenhao;  Li, Hui;  Zhang, Yao
Adobe PDF(821Kb)  |  Favorite  |    Submit date：2021/06/17
Controlleddrugdelivery  Diseases  Druginteractions  Histology  Molecules  Tumors  Ultrasonics  Anticancermolecules  Biologicaleffects  Cancertherapeutics  Drug/genedelivery  Futureperspectives  Specificdistribution  Therapeuticefficacy  Therapeuticmolecules  
Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 2, 页码: 991-1000
Authors:  Wu, Chunlei;  Cheng, Zhehong;  Lu, Danyi;  Liu, Ke;  Cheng, Yulian;  Wang, Pengxin;  Zhou, Yimin;  Li, Meiqing;  Shao, Ximing;  Li, Hongchang...Wu, Chunlei;  Cheng, Zhehong;  Lu, Danyi;  Liu, Ke;  Cheng, Yulian;  Wang, Pengxin;  Zhou, Yimin;  Li, Meiqing;  Shao, Ximing;  Li, Hongchang;  Su, Wu;  Fang, Lijing
Favorite  |    Submit date：2021/04/16