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兰州大学机构库
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3,5-二氯代酪氨酸构建新型酸激活细胞穿膜肽的设计、合成与应用
学位论文
理学博士, 兰州: 兰州大学, 2023
Authors:
薛宏祥
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Submit date:2023/11/15
细胞穿膜肽
Cell penetrating peptides
酸激活细胞穿膜肽
Acid-active cell penetrating peptides
药物递送
Drug delivery
3,5-二氯代酪氨酸
3,5-dichlorotyrosine
电荷转变
shift of charge
One New Acid-Activated Hybrid Anticancer Peptide by Coupling with a Desirable pH-Sensitive Anionic Partner Peptide
期刊论文
ACS Omega, 2023
Authors:
Chang, Linlin
;
Wu, Xiaoyan
;
Ran, Kaixin
;
Tian, Yali
;
Ouyang, Xu
;
Liu, Hui
;
Gou, Sanhu
;
Zhang, Yun
;
Ni, Jingman
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  |  
  
Submit date:2023/04/12
New designed pH-responsive histidine-rich peptides with antitumor activity
期刊论文
JOURNAL OF DRUG TARGETING, 2021, 卷号: 29, 期号: 6, 页码: 651-659
Authors:
Chang, Linlin
;
Bao, Hexin
;
Yao, Jia
;
Liu, Hui
;
Gou, Sanhu
;
Zhong, Chao
;
Zhang, Yun
;
Ni, Jingman
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  |  
  
Submit date:2021/04/16
Histidine-rich peptide
acid-activatable
antitumor
high efficiency
low toxicity
IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE(2)-mediated M2 macrophage polarization
期刊论文
Theranostics, 2020, 卷号: 10, 期号: 17, 页码: 7697-7709
Authors:
Cao, Xiaocang
;
Duan, Liyun
;
Hou, Huixing
;
Liu, Yue
;
Chen, Shang
;
Zhang, Shuaiqiang
;
Liu, Yuanyuan
;
Wang, Chen
;
Qi, Xin
;
Liu, Na
...
Cao, Xiaocang
;
Duan, Liyun
;
Hou, Huixing
;
Liu, Yue
;
Chen, Shang
;
Zhang, Shuaiqiang
;
Liu, Yuanyuan
;
Wang, Chen
;
Qi, Xin
;
Liu, Na
;
Han, Zhibo
;
Zhang, Dekui
;
Han, Zhong-Chao
;
Guo, Zhikun
;
Zhao, Qiang
;
Li, Zongji
Adobe PDF(3549Kb)
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  |  
  
Submit date:2020/08/29
Inflammatory bowel disease (IBD)
Mesenchymal stem cells (MSCs)
M2 macrophage polarization
IGF-1C hydrogel
Prostaglandin E-2 (PGE(2))
SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery
期刊论文
DRUG DELIVERY, 2020, 卷号: 27, 期号: 1, 页码: 91-99
Authors:
Song, Jingjing
;
Huang, Sujie
;
Zhang, Zhengzheng
;
Jia, Bo
;
Xie, Huan
;
Kai, Ming
;
Zhang, Wei
Adobe PDF(2089Kb)
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  |  
  
Submit date:2020/08/27
Peptide antagonist
cell penetrating peptide
camptothecin delivery
gene delivery
Design of a new pH-activatable cell-penetrating peptide for drug delivery into tumor cells
期刊论文
Chemical Biology & Drug Design, 2019, 卷号: 94, 期号: 5, 页码: 1884-1893
Authors:
Zhang, Yun
;
Li, Li
;
Chang, Linlin
;
Liu, Hui
;
Song, Jingjing
;
Liu, Yue
;
Bao, Hexin
;
Liu, Beijun
;
Wang, Rui
;
Ni, Jingman
...
Zhang, Yun
;
Li, Li
;
Chang, Linlin
;
Liu, Hui
;
Song, Jingjing
;
Liu, Yue
;
Bao, Hexin
;
Liu, Beijun
;
Wang, Rui
;
Ni, Jingman
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  |  
  
Submit date:2020/08/20
acid-activated
anticancer drug delivery
cell-penetrating peptides
low cytotoxicity
pH-dependent antitumor activity
Design of an Acid-Activated Antimicrobial Peptide for Tumor Therapy
期刊论文
MOLECULAR PHARMACEUTICS, 2013, 卷号: 10, 期号: 8, 页码: 2934-2941
Authors:
Song, JJ
;
Zhang, W
;
Kai, M
;
Chen, JB
;
Liang, RR
;
Zheng, X
;
Li, GL
;
Zhang, BZ(张邦治)
;
Wang, KR
;
Zhang, Y
...
Song, JJ
;
Zhang, W
;
Kai, M
;
Chen, JB
;
Liang, RR
;
Zheng, X
;
Li, GL
;
Zhang, BZ(张邦治)
;
Wang, KR
;
Zhang, Y
;
Yang, ZB
;
Ni, JM(倪京满)
;
Wang, R(王锐)
;
Ni, JM (reprint author), Lanzhou Univ, Sch Pharm, 222 South Tianshui Rd, Lanzhou 730000, Peoples R China.
Adobe PDF(553Kb)
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Submit date:2015/12/22
antimicrobial peptide
antitumor
acid activate
low toxicity
enzymatic stability
Design of Acid-Activated Cell Penetrating Peptide for Delivery of Active Molecules into Cancer Cells
期刊论文
BIOCONJUGATE CHEMISTRY, 2011, 卷号: 22, 期号: 7, 页码: 1410-1415
Authors:
Zhang, W
;
Song, JJ
;
Zhang, BZ(张邦治)
;
Liu, LW
;
Wang, KR
;
Wang, R(王锐)
;
Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, Lanzhou 730000, Peoples R China.
Adobe PDF(907Kb)
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Submit date:2015/12/22